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Rv0485 transcriptional regulator [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887170, updated on 6-Oct-2023

Summary

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Gene symbol
Rv0485
Gene description
transcriptional regulator
Locus tag
Rv0485
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (573984..575300)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylenolpyruvoylglucosamine reductase Neighboring gene lipoprotein LprQ Neighboring gene short-chain type oxidoreductase Neighboring gene D-inositol 3-phosphate glycosyltransferase Neighboring gene hypothetical protein Neighboring gene amino acid transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence. Goldstone RM, et al. Infect Immun, 2009 Oct. PMID 19651861, Free PMC Article
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors demonstrated that disruption of a previously uncharacterized transcriptional regulator, Rv0485, results in reduced expression of pe13 and ppe18 and attenuation of M. tuberculosis virulence.
    Title: The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence.
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General gene information

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Homology

Miscellaneous features

  • Loc: 575033-575069 mcr19, fragment of putative small regulatory RNA (See DiChiara et al., 2010), cloned from M. bovis BCG
    Pasteur; ends not mapped, 66-82 nt band detected by Northern blot in M. bovis BCG Pasteur.

General protein information

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Preferred Names
transcriptional regulator
NP_214999.1
  • NAGC/XYLR repressor family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    573984..575300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214999.1 transcriptional regulator [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_214999.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W426
    Conserved Domains (1) summary
    COG1940
    Location:102 → 420
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WKV1.1

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