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gyrB DNA gyrase subunit B [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887081, updated on 3-Sep-2024

Summary

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Gene symbol
gyrB
Gene description
DNA gyrase subunit B
Locus tag
Rv0005
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (5240..7267)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene DNA polymerase III subunit beta Neighboring gene DNA replication/repair protein RecF Neighboring gene hypothetical protein Neighboring gene DNA gyrase subunit A Neighboring gene membrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity. Petrella S, et al. Structure, 2019 Apr 2. PMID 30744994
  2. Role of gyrB Mutations in Pre-extensively and Extensively Drug-Resistant Tuberculosis in Thai Clinical Isolates. Disratthakit A, et al. Antimicrob Agents Chemother, 2016 Sep. PMID 27297489, Free PMC Article
  3. Quantification of colony-forming units for M. tuberculosis complex using gyrB-based real-time PCR assay. Yin XM, et al. Int J Tuberc Lung Dis, 2016 Jul. PMID 27287652
  4. Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion. Agrawal A, et al. Biochem J, 2013 Dec 1. PMID 24015710
  5. gyrA and gyrB mutations in ofloxacin-resistant Mycobacterium tuberculosis clinical isolates in Thailand. Pitaksajjakul P, et al. Southeast Asian J Trop Med Public Health, 2011 Sep. PMID 22299442

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Signal Propagation in the ATPase Domain of Mycobacterium tuberculosis DNA Gyrase from Dynamical-Nonequilibrium Molecular Dynamics Simulations.
    Title: Signal Propagation in the ATPase Domain of Mycobacterium tuberculosis DNA Gyrase from Dynamical-Nonequilibrium Molecular Dynamics Simulations.
  2. Molecular Characteristic of Both Levofloxacin and Moxifloxacin Resistance in Mycobacterium tuberculosis from Individuals Diagnosed with Preextensive Drug-Resistant Tuberculosis.
    Title: Molecular Characteristic of Both Levofloxacin and Moxifloxacin Resistance in Mycobacterium tuberculosis from Individuals Diagnosed with Preextensive Drug-Resistant Tuberculosis.
  3. The molecular structure of the Mycobacterium tuberculosis DNA gyrase subunit B has been reported.
    Title: Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity.
  4. Report quantification of colony-forming units for M. tuberculosis complex using gyrB-based real-time PCR assay.
    Title: Quantification of colony-forming units for M. tuberculosis complex using gyrB-based real-time PCR assay.
  5. The double mutants GyrA(A90V) GyrB(D500N) and GyrA(A90V) GyrB(T539N) are reported to be implicated in conferring higher levels of OFX resistance.
    Title: Double Mutants in DNA Gyrase Lead to Ofloxacin Resistance in Mycobacterium tuberculosis.
  6. The findings suggest that although they are rare, the Mycobacterium tuberculosis gyrB mutations have a notable role in quinolone resistance, which may provide clues to the molecular basis of estimating quinolone resistance levels for drug and dose selection.
    Title: Role of gyrB Mutations in Pre-extensively and Extensively Drug-Resistant Tuberculosis in Thai Clinical Isolates.
  7. Mutations in gyrA and gyrB among fuoroquinolone- and multidrug-resistant Mycobacterium tuberculosis Isolates have been described.
    Title: Mutations in gyrA and gyrB among Fluoroquinolone- and Multidrug-Resistant Mycobacterium tuberculosis Isolates.
  8. gyrB mutations are associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis.
    Title: Frequency and geographic distribution of gyrA and gyrB mutations associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis isolates: a systematic review.
  9. Structural evidence for the mechanochemical scheme to explain how ATP hydrolysis is coupled to domain motion in gyrB.
    Title: Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion.
  10. No mutation in the gyrB gene was found in any Mycobacterium tuberculosis strains
    Title: Characterization of gyrA and gyrB mutations and fluoroquinolone resistance in Mycobacterium tuberculosis clinical isolates from Hubei Province, China.
Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

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Homology

General protein information

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Preferred Names
DNA gyrase subunit B
NP_214519.2
  • Belongs to the type II topoisomerase family.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    5240..7267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214519.2 DNA gyrase subunit B [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_214519.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2R4IQF4, A0A2R4IQH3, A0A2R4IQJ7, R4LXV8
    Conserved Domains (1) summary
    PRK05644
    Location:5 → 675
    gyrB; DNA gyrase subunit B; Validated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WG45.1

Gene LinkOut

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Molecular Biology Databases