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ponA1 bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887065, updated on 6-Oct-2023
Gene symbol
ponA1
Gene description
bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase
Locus tag
Rv0050
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (53663..55699)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene membrane protein Neighboring gene hypothetical protein Neighboring gene transmembrane protein Neighboring gene hypothetical protein Neighboring gene 30S ribosomal protein S6

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance. Filippova EV, et al. FEBS J, 2016 Jun. PMID 27101811, Free PMC Article
  2. Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria. Kieser KJ, et al. PLoS Pathog, 2015 Jun. PMID 26114871, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural comparison of the PonA1 apo-form and the antibiotic-bound form shows that binding of penicillin V induces conformational changes in the position of the loop b4'-a3 surrounding the penicillin-binding site.
    Title: Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance.
  2. PonA1 is a central determinant of polar growth in mycobacteria
    Title: Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria.
Submit: New GeneRIF Correction

Homology

Preferred Names
bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase
YP_177687.1
  • penicillin-binding protein (class A), bienzymatic protein with transglycosylase and transpeptidase activities

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    53663..55699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177687.1 bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177687.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3M173
    Conserved Domains (3) summary
    TIGR02074
    Location:50 → 606
    PBP_1a_fam; penicillin-binding protein, 1A family
    pfam00905
    Location:310 → 601
    Transpeptidase; Penicillin binding protein transpeptidase domain
    pfam00912
    Location:37 → 218
    Transgly; Transglycosylase
Nucleotide Protein
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