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pknH serine/threonine-protein kinase PknH [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887023, updated on 6-Oct-2023
Gene symbol
pknH
Gene description
serine/threonine-protein kinase PknH
Locus tag
Rv1266c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (1413960..1415840, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene transcriptional regulator EmbR Neighboring gene hypothetical protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice. Papavinasasundaram KG, et al. J Bacteriol, 2005 Aug. PMID 16077122, Free PMC Article
  2. Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis. Gómez-Velasco A, et al. Microbiology (Reading), 2013 Apr. PMID 23412844, Free PMC Article
  3. Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis. Chao JD, et al. J Biol Chem, 2010 Sep 17. PMID 20630871, Free PMC Article
  4. EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR. Molle V, et al. Biochem J, 2008 Mar 1. PMID 17999640
  5. Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Zheng X, et al. Biochem Biophys Res Commun, 2007 Mar 30. PMID 17286964

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PknH contributes to the production and synthesis of M. tuberculosis cell-wall components.
    Title: Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis.
  2. Results indicate that PknH phosphorylation of DosR is required for full induction of the DosR regulon and demonstrate convergence of the two major signal transduction systems for the first time in M. tuberculosis.
    Title: Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis.
  3. EmbR2 is a regulator of PknH activation, thus directly participating in the control of the PknH/EmbR pair and potentially in mycobacterial physiology/virulence of M. tuberculosis
    Title: EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR.
  4. the serine/threonine kinase PknH plays a role in regulating bacillary load in mouse organs to facilitate adaptation to the host environment, possibly by enabling a regulated chronic infection by M. tuberculosis
    Title: Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice.
  5. These findings and in vivo upregulation of PknH inside the host macrophages suggest a functionally relevant signaling mechanism involving the PknH-EmbR-embCAB system.
    Title: Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo.
  6. PknH kinase can phosphorylate several substrates controlling different metabolic and physiological pathways.
    Title: Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase.
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Homology

Preferred Names
serine/threonine-protein kinase PknH

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1413960..1415840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215782.1 serine/threonine-protein kinase PknH [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215782.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M524
    Conserved Domains (3) summary
    smart00220
    Location:16 → 279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14014
    Location:15 → 269
    STKc_PknB_like; Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins
    pfam14032
    Location:438 → 622
    PknH_C; PknH-like extracellular domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WI71.1

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