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dnaB replicative DNA helicase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887009, updated on 6-Aug-2024
Gene symbol
dnaB
Gene description
replicative DNA helicase
Locus tag
Rv0058
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (60396..63020)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 30S ribosomal protein S18 Neighboring gene 50S ribosomal protein L9 Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Hexameric ring structure of the N-terminal domain of Mycobacterium tuberculosis DnaB helicase. Biswas T, et al. FEBS J, 2008 Jun. PMID 18479467
  2. Structural insights into the interaction of helicase and primase in Mycobacterium tuberculosis. Sharma DP, et al. Biochem J, 2018 Nov 15. PMID 30315069
  3. Characterization of physical interaction between replication initiator protein DnaA and replicative helicase from Mycobacterium tuberculosis H37Rv. Xie Y, et al. Biochemistry (Mosc), 2009 Dec. PMID 19961412
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Helicase-primase in Mycobacterium tuberculosis interaction complex was modeled using the MtDnaG-C-terminal domain (CTD) and MtDnaB-N-terminal domain (NTD) crystal structures.
    Title: Structural insights into the interaction of helicase and primase in Mycobacterium tuberculosis.
  2. The N-terminus of DnaB also had a critical role in regulating DnaA complex formation at the origin of replication.
    Title: Characterization of physical interaction between replication initiator protein DnaA and replicative helicase from Mycobacterium tuberculosis H37Rv.
  3. A model of a helicase-primase complex that explains previously observed effects of DnaB mutations on DNA priming.
    Title: Hexameric ring structure of the N-terminal domain of Mycobacterium tuberculosis DnaB helicase.
Submit: New GeneRIF Correction

Homology

Preferred Names
replicative DNA helicase
NP_214572.1
  • Contains an intein (position 61630..62838). This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation. In the intein section; belongs to the homing endonuclease family.

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    60396..63020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214572.1 replicative DNA helicase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_214572.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4MDF4
    Conserved Domains (1) summary
    PRK07773
    Location:1 → 874
    PRK07773; replicative DNA helicase; Validated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WMR3.1

Gene LinkOut

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Research Materials