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nrp peptide synthetase Nrp [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886951, updated on 20-Feb-2025
Gene symbol
nrp
Gene description
peptide synthetase Nrp
Locus tag
Rv0101
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (110001..117539)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene oxidoreductase Neighboring gene fatty acyl CoA thioesterase FcoT Neighboring gene fatty-acid--CoA ligase FadD10 Neighboring gene hypothetical protein Neighboring gene integral membrane protein Neighboring gene cation-transporter P-type ATPase B

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis. Bhatt K, et al. mSphere, 2018 Oct 31. PMID 30381350, Free PMC Article
  2. Delineating the reaction mechanism of reductase domains of Nonribosomal Peptide Synthetases from mycobacteria. Haque AS, et al. J Struct Biol, 2014 Sep. PMID 25108240
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors propose that the nrp gene and its associated cluster are drivers of virulence during the early stages of infection.
    Title: A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis.
  2. Data show that mutation of catalytic tyrosine to phenylalanine in R-domain of nonribosomal peptide synthetase (RNRP) results in 3-4-fold decrease in affinity for NADPH.
    Title: Delineating the reaction mechanism of reductase domains of Nonribosomal Peptide Synthetases from mycobacteria.
Submit: New GeneRIF Correction

Homology

Preferred Names
peptide synthetase Nrp
NP_214615.1
  • Belongs to the ATP-dependent AMP-binding enzyme family.

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    110001..117539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214615.1 peptide synthetase Nrp [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_214615.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q7DAG9
    Conserved Domains (3) summary
    COG1020
    Location:280 → 846
    EntF; Non-ribosomal peptide synthetase component F [Secondary metabolites biosynthesis, transport and catabolism]
    COG3320
    Location:2108 → 2512
    Lys2b; Thioester reductase domain of alpha aminoadipate reductase Lys2 and NRPSs [Secondary metabolites biosynthesis, transport and catabolism]
    PRK12467
    Location:575 → 2027
    PRK12467; peptide synthase; Provisional
Nucleotide Protein
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