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rfe decaprenyl-phosphate N-acetylglucosaminephosphotransferase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886947, updated on 6-Oct-2023
Gene symbol
rfe
Gene description
decaprenyl-phosphate N-acetylglucosaminephosphotransferase
Locus tag
Rv1302
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
wecA
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Sequence:
NC_000962.3 (1458295..1459509)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene peptide chain release factor PrfA Neighboring gene release factor glutamine methyltransferase Neighboring gene threonylcarbamoyl-AMP synthase Neighboring gene hypothetical protein Neighboring gene ATP synthase subunit A Neighboring gene ATP synthase subunit C

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis. Huszár S, et al. Antimicrob Agents Chemother, 2017 Nov. PMID 28874370, Free PMC Article
  2. Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors. Mitachi K, et al. Anal Biochem, 2016 Nov 1. PMID 27530653, Free PMC Article
  3. Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45. Ishizaki Y, et al. J Biol Chem, 2013 Oct 18. PMID 23986448, Free PMC Article
  4. Mycobacterium tuberculosis Rv1302 and Mycobacterium smegmatis MSMEG_4947 have WecA function and MSMEG_4947 is required for the growth of M. smegmatis. Jin Y, et al. FEMS Microbiol Lett, 2010 Sep 1. PMID 20637039
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WecA is essential in M. tuberculosis.
    Title: N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis.
  2. Screening of the compound libraries designed for bacterial phosphotransferases resulted in the discovery of a selective WecA inhibitor, UT-01320 (12) that kills both replicating and non-replicating Mycobacterium tuberculosis at low concentration.
    Title: Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors.
  3. CPZEN-45 was effective against WecA (Rv1302, also called Rfe) of Mycobacterium tuberculosis, the ortholog of TagO and involved in the biosynthesis of the mycolylarabinogalactan of the cell wall of M. tuberculosis
    Title: Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45.
  4. This study provides the first evidence that Rv1302 and MSMEG_4947 have the same function as Escherichia coli WecA.
    Title: Mycobacterium tuberculosis Rv1302 and Mycobacterium smegmatis MSMEG_4947 have WecA function and MSMEG_4947 is required for the growth of M. smegmatis.
Submit: New GeneRIF Correction

Homology

Preferred Names
decaprenyl-phosphate N-acetylglucosaminephosphotransferase
NP_215818.1
  • UDP-GlcNAc transferase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1458295..1459509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215818.1 decaprenyl-phosphate N-acetylglucosaminephosphotransferase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215818.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M677
    Conserved Domains (1) summary
    cd06853
    Location:67 → 341
    GT_WecA_like; This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WMW5.1

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