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ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [ Homo sapiens (human) ]

Gene ID: 8869, updated on 21-Apr-2019

Summary

Official Symbol
ST3GAL5provided by HGNC
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 5provided by HGNC
Primary source
HGNC:HGNC:10872
See related
Ensembl:ENSG00000115525 MIM:604402
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SATI; SIAT9; SPDRS; ST3GalV; SIATGM3S; ST3Gal V
Summary
Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in adrenal (RPKM 17.6), thyroid (RPKM 16.1) and 23 other tissues See more
Orthologs

Genomic context

See ST3GAL5 in Genome Data Viewer
Location:
2p11.2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (85839133..85889034, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (86066271..86116157, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene atonal bHLH transcription factor 8 Neighboring gene microRNA 6071 Neighboring gene uncharacterized LOC284950 Neighboring gene RN7SK pseudogene 83 Neighboring gene ST3GAL5 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC112268420

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ST3 beta-galactoside alpha-2,3-sialyltransferase 5 (ST3GAL5) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag HIV-1 NC upregulates ST3 beta-galactoside alpha-2,3-sialyltransferase 5 in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
ganglioside biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
glycosphingolipid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
sialylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane NAS
Non-traceable Author Statement
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
lactosylceramide alpha-2,3-sialyltransferase
Names
CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
ST3 beta-galactoside alpha-23-sialyltransferase 5
alpha 2,3-sialyltransferase V
ganglioside GM3 synthase
sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase)
NP_001035902.1
NP_001341152.1
NP_001341153.1
NP_001341155.1
NP_001341156.1
NP_001341158.1
NP_001341162.1
NP_001341163.1
NP_001341167.1
NP_001341176.1
NP_001341177.1
NP_003887.3
XP_005264687.1
XP_016860691.1
XP_016860692.1
XP_016860693.1
XP_016860694.1
XP_016860695.1
XP_016860697.1
XP_016860698.1
XP_016860701.1
XP_016860702.1
XP_016860703.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012807.1 RefSeqGene

    Range
    5001..54887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042437.1NP_001035902.1  lactosylceramide alpha-2,3-sialyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001035902.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a novel 5' exon compared to transcript variant 1, and encodes a shorter isoform (2) with a different N-terminus compared to isoform 1.
    Source sequence(s)
    AY152815
    Consensus CDS
    CCDS42705.1
    UniProtKB/Swiss-Prot
    Q9UNP4
    Related
    ENSP00000377397.3, ENST00000393808.8
    Conserved Domains (1) summary
    pfam00777
    Location:121387
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_001354223.1NP_001341152.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105053
    Conserved Domains (1) summary
    pfam00777
    Location:27282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. NM_001354224.1NP_001341153.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105053
    Conserved Domains (1) summary
    pfam00777
    Location:27282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. NM_001354226.1NP_001341155.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105053
    Conserved Domains (1) summary
    pfam00777
    Location:27282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. NM_001354227.1NP_001341156.1  lactosylceramide alpha-2,3-sialyltransferase isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC105053
    Consensus CDS
    CCDS86856.1
    Related
    ENSP00000492299.1, ENST00000640982.1
    Conserved Domains (1) summary
    pfam00777
    Location:127382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. NM_001354229.1NP_001341158.1  lactosylceramide alpha-2,3-sialyltransferase isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC105053
    Consensus CDS
    CCDS86856.1
    Related
    ENSP00000491853.1, ENST00000638986.1
    Conserved Domains (1) summary
    pfam00777
    Location:127382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. NM_001354233.1NP_001341162.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105053
    Conserved Domains (1) summary
    pfam00777
    Location:27282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  8. NM_001354234.1NP_001341163.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105053
    Conserved Domains (1) summary
    pfam00777
    Location:27282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  9. NM_001354238.1NP_001341167.1  lactosylceramide alpha-2,3-sialyltransferase isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC105053, AF105026
    Consensus CDS
    CCDS86856.1
    Related
    ENSP00000377394.1, ENST00000393805.6
    Conserved Domains (1) summary
    pfam00777
    Location:127382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  10. NM_001354247.1NP_001341176.1  lactosylceramide alpha-2,3-sialyltransferase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC105053
    Conserved Domains (1) summary
    pfam00777
    Location:1169
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  11. NM_001354248.1NP_001341177.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105053
    Conserved Domains (1) summary
    pfam00777
    Location:27282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  12. NM_001363847.1NP_001350776.1  lactosylceramide alpha-2,3-sialyltransferase isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC105053
    Consensus CDS
    CCDS86857.1
    Conserved Domains (1) summary
    pfam00777
    Location:155357
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  13. NM_003896.4NP_003887.3  lactosylceramide alpha-2,3-sialyltransferase isoform 1

    See identical proteins and their annotated locations for NP_003887.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB018356, AC105053, AK001340, CA503200
    Consensus CDS
    CCDS1986.2
    UniProtKB/Swiss-Prot
    Q9UNP4
    Related
    ENSP00000491316.1, ENST00000638572.2
    Conserved Domains (1) summary
    pfam00777
    Location:144410
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    85839133..85889034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264630.4XP_005264687.1  lactosylceramide alpha-2,3-sialyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A1W2PR45
    Related
    ENSP00000492045.1, ENST00000639119.1
    Conserved Domains (1) summary
    pfam00777
    Location:155357
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_017005203.2XP_016860692.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:27282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_017005202.2XP_016860691.1  lactosylceramide alpha-2,3-sialyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z4Q7
    Related
    ENSP00000492103.1, ENST00000638178.1
    Conserved Domains (1) summary
    pfam00777
    Location:116329
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. XM_017005214.2XP_016860703.1  lactosylceramide alpha-2,3-sialyltransferase isoform X4

  5. XM_017005205.2XP_016860694.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:27282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. XM_017005206.2XP_016860695.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:27282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. XM_017005208.2XP_016860697.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:27282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  8. XM_017005204.2XP_016860693.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:27282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  9. XM_017005209.1XP_016860698.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:27282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  10. XM_017005212.2XP_016860701.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:27282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  11. XM_017005213.2XP_016860702.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:27282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_001739019.1 RNA Sequence

    Related
    ENST00000640425.1
  2. XR_001739020.1 RNA Sequence

    Related
    ENST00000639541.1
  3. XR_001739021.1 RNA Sequence

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