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glgE alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886895, updated on 6-Oct-2023
Gene symbol
glgE
Gene description
alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase
Locus tag
Rv1327c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (1492320..1494425, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene PE-PGRS family protein PE_PGRS24 Neighboring gene 1,4-alpha-glucan branching protein Neighboring gene glycogen phosphorylase Neighboring gene ATP-dependent helicase DinG

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors. Lindenberger JJ, et al. Sci Rep, 2015 Aug 6. PMID 26245983, Free PMC Article
  2. Structural insight into Mycobacterium tuberculosis maltosyl transferase inhibitors: pharmacophore-based virtual screening, docking, and molecular dynamics simulations. Sengupta S, et al. J Biomol Struct Dyn, 2015. PMID 25669125
  3. Modeling of a new tubercular maltosyl transferase, GlgE, study of its binding sites and virtual screening. Sengupta S, et al. Mol Biol Rep, 2014 Jun. PMID 24820953
  4. Mycobacterium tuberculosis maltosyltransferase GlgE, a genetically validated antituberculosis target, is negatively regulated by Ser/Thr phosphorylation. Leiba J, et al. J Biol Chem, 2013 Jun 7. PMID 23609448, Free PMC Article
  5. Structure of Streptomyces maltosyltransferase GlgE, a homologue of a genetically validated anti-tuberculosis target. Syson K, et al. J Biol Chem, 2011 Nov 4. PMID 21914799, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studies show stable maltosyl transferasev protein ligand binding, indicating potential target for antitubercular therapeutic development.
    Title: Structural insight into Mycobacterium tuberculosis maltosyl transferase inhibitors: pharmacophore-based virtual screening, docking, and molecular dynamics simulations.
  2. Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors.
    Title: Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors.
  3. This reveals for the first time the unique 3D structure of mtb GlgE and provides insights into its active sites and substrate binding affinities.
    Title: Modeling of a new tubercular maltosyl transferase, GlgE, study of its binding sites and virtual screening.
  4. GlgE pathway appears to be negatively regulated in actinomycetes through the phosphorylation of GlgE by PknB, a mechanism distinct from that known in the classical glycogen pathway.
    Title: Mycobacterium tuberculosis maltosyltransferase GlgE, a genetically validated antituberculosis target, is negatively regulated by Ser/Thr phosphorylation.
  5. analysis of GlgE from Streptomyces and Mycobacterium tuberculosis
    Title: Structure of Streptomyces maltosyltransferase GlgE, a homologue of a genetically validated anti-tuberculosis target.
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Homology

Preferred Names
alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1492320..1494425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215843.2 alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215843.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4LWZ7
    Conserved Domains (2) summary
    cd11344
    Location:231 → 590
    AmyAc_GlgE_like; Alpha amylase catalytic domain found in GlgE-like proteins
    pfam11896
    Location:16 → 226
    DUF3416; Domain of unknown function (DUF3416)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WQ17.1

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Molecular Biology Databases