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inhA NADH-dependent enoyl-[ACP] reductase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886523, updated on 6-Oct-2023
Gene symbol
inhA
Gene description
NADH-dependent enoyl-[ACP] reductase
Locus tag
Rv1484
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Try the new Transcripts and proteins table
Sequence:
NC_000962.3 (1674202..1675011)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene 3-oxoacyl-ACP reductase FabG Neighboring gene ferrochelatase Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors. Ibrahim TS, et al. Molecules, 2020 Jul 8. PMID 32650556, Free PMC Article
  2. Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Vilchèze C, et al. Nat Med, 2006 Sep. PMID 16906155
  3. Evidence from Raman spectroscopy that InhA, the mycobacterial enoyl reductase, modulates the conformation of the NADH cofactor to promote catalysis. Bell AF, et al. J Am Chem Soc, 2007 May 23. PMID 17472376
  4. Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis. Dias MV, et al. J Struct Biol, 2007 Sep. PMID 17588773
  5. Phosphorylation of enoyl-acyl carrier protein reductase InhA impacts mycobacterial growth and survival. Khan S, et al. J Biol Chem, 2010 Nov 26. PMID 20864541, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pattern of InhA and KatG mutations in isoniazid mono resistant Mycobacterium tuberculosis isolates from Odisha.
    Title: Pattern of InhA and KatG mutations in isoniazid mono resistant Mycobacterium tuberculosis isolates from Odisha.
  2. In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors.
    Title: In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors.
  3. Identification of Novel Cytotoxic T Lymphocyte Epitopes of Drug- Resistance Related Protein InhA from Mycobacterium tuberculosis.
    Title: Identification of Novel Cytotoxic T Lymphocyte Epitopes of Drug- Resistance Related Protein InhA from Mycobacterium tuberculosis.
  4. This study provides valuable information on the diversity of polymorphisms in genes related to multidrug-resistant tuberculosis (including inhA), as well as the presence of new mutations not previously described; this information should be considered in the implementation of molecular diagnostic tests
    Title: rpoB, katG and inhA mutations in multi-drug resistant strains of Mycobacterium tuberculosis clinical isolates from southeast Mexico.
  5. Among the inhibin alpha promoter region mutations, 2(6.6%) of the thirty isoniazid resistant isolates had the most common C15T mutation in the promoter region.
    Title: Molecular characterisation of isoniazid resistant clinical isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan.
  6. The formation of a covalent adduct during the InhA catalytic cycle and identified critical residues required for catalysis.
    Title: InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis.
  7. It showed two molecules with comparatively higher affinity toward InhA as compared to potent molecule. It indicated the candidature of identified molecules to be further considered in anti-TB drug development pipeline.
    Title: Cell wall permeability assisted virtual screening to identify potential direct InhA inhibitors of Mycobacterium tuberculosis and their biological evaluation.
  8. Studied DNA-directed RNA polymerase subunit beta (rpoB), catalase-peroxidase (katG) and NADH-dependent enoyl-[ACP] reductase (inhA) mutations in clinical drug resistant Mycobacterium tuberculosis isolates.
    Title: Differences in rpoB, katG and inhA mutations between new and previously treated tuberculosis cases using the GenoType MTBDRplus assay.
  9. Study examine previously unstudied catalytic pocket residues through mutations in terms of their kinetics relating to NADH and DD-CoA substrate binding and turnover. The results demonstrate that mutation of NADH-binding pocket residues can have profound effects on DD-CoA binding and suggest that there are long range molecular interactions in the InhA protein.
    Title: Disruption of key NADH-binding pocket residues of the Mycobacterium tuberculosis InhA affects DD-CoA binding ability.
  10. Out of the 141 isolates studied, 3 (2.1%) were found carrying mutations in the katG gene that confer resistance to Isoniazid (INH). No mutations were detected in the inhA promoter region gene that confer weak INH resistance or in the rpoB gene that confer Rifampicin resistance.
    Title: The occurrence and frequency of genomic mutations that mediate Isoniazid and Rifampicin resistance in Mycobacterium tuberculosis isolates from untreated pulmonary Tuberculosis cases in urban Blantyre, Malawi.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Homology

Preferred Names
NADH-dependent enoyl-[ACP] reductase
NP_216000.1
  • NADH-dependent enoyl-ACP reductase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1674202..1675011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216000.1 NADH-dependent enoyl-[ACP] reductase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216000.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A4Y5N117, Q4TUY1
    Conserved Domains (1) summary
    PRK07889
    Location:1 → 269
    PRK07889; enoyl-[acyl-carrier-protein] reductase FabI
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2NSD_A.1
2NSD_B.1
2PR2_A.1
2X22_A.1
2X22_B.1
2X23_A.1
2X23_B.1
2X23_E.1
2X23_G.1
3OEW_A.1
4BII_A.1
4BII_B.1
4BII_C.1
4BII_D.1
4BQP_A.1
4BQP_B.1
4BQP_C.1
4BQP_D.1
4BQP_E.1
4BQP_F.1
4BQR_A.1
4BQR_B.1
4BQR_C.1
4BQR_D.1
4D0S_A.1
4D0S_B.1
4D0S_C.1
4D0S_D.1
4QXM_A.1
4QXM_C.1
4QXM_E.1
4QXM_G.1
4TZK_A.1
4TZT_A.1
4U0J_A.1
4U0K_A.1
4UVD_A.1
4UVE_A.1
4UVG_A.1
4UVH_A.1
4UVH_B.1
4UVH_C.1
4UVH_D.1
4UVI_A.1
4UVI_B.1
4UVI_C.1
4UVI_D.1
5G0S_A.1
5G0S_B.1
5G0S_C.1
5G0S_D.1
5G0T_A.1
5G0T_B.1
5G0T_C.1
5G0T_D.1
5G0U_A.1
5G0U_B.1
5G0U_C.1
5G0U_D.1
5G0V_A.1
5G0V_B.1
5G0V_C.1
5G0V_D.1
5G0W_A.1
5G0W_B.1
5G0W_C.1
5G0W_D.1
5JFO_A.1
5JFO_B.1
5JFO_C.1
5JFO_D.1
P9WGR1.1

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