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fba fructose-bisphosphate aldolase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886474, updated on 6-Oct-2023
Gene symbol
fba
Gene description
fructose-bisphosphate aldolase
Locus tag
Rv0363c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
fda
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Sequence:
NC_000962.3 (441265..442299, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene membrane protein Neighboring gene Mg2+ transport transmembrane protein MgtE Neighboring gene transmembrane protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis. Puckett S, et al. PLoS Pathog, 2014 May. PMID 24851864, Free PMC Article
  2. Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis. Pegan SD, et al. Biochemistry, 2013 Feb 5. PMID 23298222, Free PMC Article
  3. Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli. de la Paz Santangelo M, et al. J Biol Chem, 2011 Nov 18. PMID 21949126, Free PMC Article
  4. Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis. Pegan SD, et al. J Mol Biol, 2009 Mar 6. PMID 19167403, Free PMC Article
  5. Molecular cloning, expression, purification, and characterization of fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis--a novel Class II A tetramer. Ramsaywak PC, et al. Protein Expr Purif, 2004 Sep. PMID 15294302

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In vitro studies of Deltafba revealed that lack of FBA could only be compensated for by a specific balance of glucose and butyrate in which growth and metabolism of butyrate were determined by Mycobacterium tuberculosis's ability to co-catabolize glucose.
    Title: Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.
  2. Determined is the the X-ray structure of the Fba-inhibitor phosphoglycolohydroxamate complex to 1.58 A.
    Title: Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis.
  3. Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
    Title: Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
  4. The X-ray structure of MtFBA in complex with its substrates, was determined.
    Title: Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis.
  5. cloning, purification & characterization of fructose 1,6-bisphosphate aldolase; first Class II Type A aldolase found in the tetrameric form & its catalytic efficiency for FBP cleavage is also highest among the Class II A aldolases characterized to date
    Title: Molecular cloning, expression, purification, and characterization of fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis--a novel Class II A tetramer.
Submit: New GeneRIF Correction

Homology

Preferred Names
fructose-bisphosphate aldolase
NP_214877.1
  • Belongs to class II fructose-bisphosphate aldolase family. Cofactor: zinc.

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    441265..442299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214877.1 fructose-bisphosphate aldolase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_214877.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M2C3
    Conserved Domains (1) summary
    PRK09197
    Location:1 → 342
    PRK09197; fructose-bisphosphate aldolase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WQA3.1

Gene LinkOut

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