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bioD ATP-dependent dethiobiotin synthetase BioD [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886338, updated on 6-Oct-2023
Gene symbol
bioD
Gene description
ATP-dependent dethiobiotin synthetase BioD
Locus tag
Rv1570
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (1777859..1778539)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene membrane protein Neighboring gene adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA Neighboring gene 8-amino-7-oxononanoate synthase Neighboring gene hypothetical protein Neighboring gene phage protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase. Thompson AP, et al. Acta Crystallogr D Struct Biol, 2018 Oct 1. PMID 30289406
  2. Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase. Salaemae W, et al. Tuberculosis (Edinb), 2015 May. PMID 25801336
  3. Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase . Dey S, et al. Biochemistry, 2010 Aug 10. PMID 20565114, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Precipitant-ligand exchange also yielded the previously intractable structure of MtDTBS in complex with ADP solved to 2.4 A resolution.
    Title: Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.
  2. Mycobacterium tuberculosis DTBS has a broad nucleotide specificity due to the absence of the gate-keeper residue.
    Title: Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase.
  3. the crystal structures 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase; derivation of an enzyme mechanism
    Title: Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
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Homology

Preferred Names
ATP-dependent dethiobiotin synthetase BioD

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1777859..1778539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216086.1 ATP-dependent dethiobiotin synthetase BioD [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216086.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M5J2
    Conserved Domains (1) summary
    COG0132
    Location:12 → 218
    BioD; Dethiobiotin synthetase [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WPQ5.1

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