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espB ESX-1 secretion-associated protein EspB [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886214, updated on 12-Feb-2021
Gene symbol
espB
Gene description
ESX-1 secretion-associated protein EspB
Locus tag
Rv3881c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (4360543..4361925, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene ESX-1 secretion-associated protein EspJ Neighboring gene ESX-1 secretion-associated protein EspK Neighboring gene ESX-1 secretion-associated protein EspL Neighboring gene ESX-1 secretion system protein EccE1 Neighboring gene membrane-anchored mycosin Neighboring gene ESX-2 secretion system protein EccA

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mycobacterium tuberculosis EspB protein suppresses interferon-γ-induced autophagy in murine macrophages. Huang D, et al. J Microbiol Immunol Infect, 2016 Dec. PMID 25641595
  2. Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis. Korotkova N, et al. J Struct Biol, 2015 Aug. PMID 26051906, Free PMC Article
  3. A mycobacterium ESX-1-secreted virulence factor with unique requirements for export. McLaughlin B, et al. PLoS Pathog, 2007 Aug 3. PMID 17676952, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EspB inhibits autophagosome formation in murine macrophages, at least in part by downregulating IFN-gamma receptor 1 expression. Overall, EspB should be considered a relevant factor in the pathogenesis of mycobacterial infections in humans.
    Title: Mycobacterium tuberculosis EspB protein suppresses interferon-γ-induced autophagy in murine macrophages.
  2. The structure of full-length EspB is presented.
    Title: Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

Homology

Preferred Names
ESX-1 secretion-associated protein EspB

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4360543..4361925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218398.1 ESX-1 secretion-associated protein EspB [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218398.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P9WJD9
    UniProtKB/TrEMBL
    I6YHD6
    Conserved Domains (1) summary
    pfam18625
    Location:12 → 88
    EspB_PE; ESX-1 secreted protein B PE domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6XZC_A.1
6XZC_B.1
6XZC_C.1
6XZC_D.1
6XZC_E.1
6XZC_F.1
6XZC_G.1
P9WJD9.1

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