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whiB6 transcriptional regulator WhiB6 [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886190, updated on 6-Oct-2023
Gene symbol
whiB6
Gene description
transcriptional regulator WhiB6
Locus tag
Rv3862c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
whmF
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Sequence:
NC_000962.3 (4338171..4338521, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene glutamate synthase small subunit Neighboring gene glutamate synthase large subunit Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene ESX-1 secretion-associated protein EspE

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component. Solans L, et al. Infect Immun, 2014 Aug. PMID 24891105, Free PMC Article
  2. Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator. Abdallah AM, et al. PLoS One, 2019. PMID 30673778, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these data show that WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates and that ESX-1 substrates are regulated independently from the structural components, both during infection and as a result of active secretion.
    Title: Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator.
  2. Authors provide clear evidence ESX-1 expression is regulated by WhiB6 as part of the PhoP regulon, which adds another level of complexity to the regulation of ESAT-6 secretion with a potential role in virulence adaptation.
    Title: A specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component.
Submit: New GeneRIF Correction

Homology

Preferred Names
transcriptional regulator WhiB6

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4338171..4338521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218379.1 transcriptional regulator WhiB6 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218379.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M8H8
    Conserved Domains (1) summary
    pfam02467
    Location:48 → 79
    Whib; Transcription factor WhiB
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WF37.1

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