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espR ESX-1 transcriptional regulator EspR [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886184, updated on 6-Aug-2024
Gene symbol
espR
Gene description
ESX-1 transcriptional regulator EspR
Locus tag
Rv3849
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (4323499..4323897)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene transmembrane protein Neighboring gene hypothetical protein Neighboring gene membrane protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Atypical DNA recognition mechanism used by the EspR virulence regulator of Mycobacterium tuberculosis. Blasco B, et al. Mol Microbiol, 2011 Oct. PMID 21883526
  2. EspR-dependent ESAT-6 Protein Secretion of Mycobacterium tuberculosis Requires the Presence of Virulence Regulator PhoP. Anil Kumar V, et al. J Biol Chem, 2016 Sep 2. PMID 27445330, Free PMC Article
  3. EspR, a regulator of the ESX-1 secretion system in Mycobacterium tuberculosis, is directly regulated by the two-component systems MprAB and PhoPR. Cao G, et al. Microbiology (Reading), 2015 Mar. PMID 25536998
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a model is proposed suggesting how PhoP and EspR protein-protein interactions contribute to activation of espACD expression and, in turn, control ESAT-6 secretion, an essential pathogenic determinant of M. tuberculosis
    Title: EspR-dependent ESAT-6 Protein Secretion of Mycobacterium tuberculosis Requires the Presence of Virulence Regulator PhoP.
  2. EspR is directly regulated by the two-component systems MprAB and PhoPR.
    Title: EspR, a regulator of the ESX-1 secretion system in Mycobacterium tuberculosis, is directly regulated by the two-component systems MprAB and PhoPR.
  3. EspR forms a dimer with each monomer containing an N-terminal helix-turn-helix DNA binding motif and an C-terminal dimerization domain.
    Title: Atypical DNA recognition mechanism used by the EspR virulence regulator of Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

Homology

Preferred Names
ESX-1 transcriptional regulator EspR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4323499..4323897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218366.1 ESX-1 transcriptional regulator EspR [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218366.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3LN28
    Conserved Domains (1) summary
    cl01416
    Location:23 → 119
    Fimbrial; Fimbrial protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WJB7.1

Gene LinkOut

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Molecular Biology Databases
Research Materials