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bfrB bacterioferritin BfrB [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886176, updated on 11-Dec-2020
Gene symbol
bfrB
Gene description
bacterioferritin BfrB
Locus tag
Rv3841
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (4314178..4314723)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene transcriptional regulator Neighboring gene glycerophosphoryl diester phosphodiesterase Neighboring gene transmembrane protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results found that BfrB, identified here for the first time as an Mtb effector, subverts the host innate immune system by binding the NF-kappaB subunit RPS3 and promotes the survival of mycobacteria in macrophages by inhibiting cytokine production in host cells.
    Title: Systematic Identification of Mycobacterium tuberculosis Effectors Reveals that BfrB Suppresses Innate Immunity.
  2. ferritin interacted with few proteins which are directly and indirectly involved in M. tuberculosis growth, Iron assimilation, virulence, resistance, stresses and latency.
    Title: M. tuberculosis ferritin (Rv3841): Potential involvement in Amikacin (AK) & Kanamycin (KM) resistance.
  3. Mt-Enc encapsulation of three enzymes, Mt-DyP, Mt-BfrB, and Mt-FolB.
    Title: Characterization of a Mycobacterium tuberculosis nanocompartment and its potential cargo proteins.
  4. Residues R69, L129, and F159 act as "switch points" for oligomerization, and importance of 4-fold axis residues in assembly formation. Mutations Q51A, Q126A, and E135A can enhance thermal stability without affecting its assembly.
    Title: Unique residues at the 3-fold and 4-fold axis of mycobacterial ferritin are involved in oligomer switching.
  5. BfrA and bfrB are essential for the survival and pathogenesis of Mycobacterium tuberculosis in THP-1 macrophages.
    Title: Iron storage proteins are essential for the survival and pathogenesis of Mycobacterium tuberculosis in THP-1 macrophages and the guinea pig model of infection.
  6. Crystallization and preliminary X-ray diffraction analysis of the ferritin homolog (Mtb BfrB, Rv3841) is reported.
    Title: Crystallization and preliminary X-ray crystallographic analysis of a Mycobacterium tuberculosis ferritin homolog, BfrB.
  7. Nox19 is induced by the nitrogen oxide donor nitroprusside
    Title: Response to reactive nitrogen intermediates in Mycobacterium tuberculosis: induction of the 16-kilodalton alpha-crystallin homolog by exposure to nitric oxide donors.
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Homology

Preferred Names
bacterioferritin BfrB

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4314178..4314723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218358.1 bacterioferritin BfrB [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218358.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    COG1528
    Location:7 → 175
    Ftn; Ferritin [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WNE5.1

Gene LinkOut

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