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dprE1 decaprenylphosphoryl-beta-D-ribose oxidase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886125, updated on 6-Oct-2023

Summary

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Gene symbol
dprE1
Gene description
decaprenylphosphoryl-beta-D-ribose oxidase
Locus tag
Rv3790
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (4235779..4237164)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene GtrA family protein Neighboring gene decaprenylphosphoryl-D-2-keto erythropentose reductase Neighboring gene arabinofuranosyltransferase Neighboring gene arabinosyltransferase C

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1. Richter A, et al. Sci Rep, 2018 Sep 7. PMID 30194385, Free PMC Article
  2. Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis. Foo CS, et al. Antimicrob Agents Chemother, 2016 Nov. PMID 27527085, Free PMC Article
  3. Structure, dynamics, and interaction of Mycobacterium tuberculosis (Mtb) DprE1 and DprE2 examined by molecular modeling, simulation, and electrostatic studies. Bhutani I, et al. PLoS One, 2015. PMID 25789990, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1.
    Title: Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1.
  2. Characterization of DprE1-mediated benzothiazinone resistance in Mycobacterium tuberculosis has been reported.
    Title: Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis.
  3. we hypothesize that DprE1-DprE2 interaction is crucial for the synthesis of DPA and DprE1-DprE2 complex may be a new therapeutic target amenable to pharmacological validation. The findings have important implications in tuberculosis (TB) drug discovery
    Title: Structure, dynamics, and interaction of Mycobacterium tuberculosis (Mtb) DprE1 and DprE2 examined by molecular modeling, simulation, and electrostatic studies.
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Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
decaprenylphosphoryl-beta-D-ribose oxidase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4235779..4237164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218307.1 decaprenylphosphoryl-beta-D-ribose oxidase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218307.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A655D053
    Conserved Domains (1) summary
    COG0277
    Location:10 → 459
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
4KW5_A.1
4KW5_B.1
P9WJF1.1

Gene LinkOut

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Molecular Biology Databases
Research Materials