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Rv1049 transcriptional repressor [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886091, updated on 6-Oct-2023

Summary

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Gene symbol
Rv1049
Gene description
transcriptional repressor
Locus tag
Rv1049
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1172386..1172832)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene transposase Neighboring gene hypothetical protein Neighboring gene oxidoreductase Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Computer simulations reveal changes in the conformational space of the transcriptional regulator MosR upon the formation of a disulphide bond and in the collective motions that regulate its DNA-binding affinity. Câmara AS, et al. PLoS One, 2018. PMID 29470546, Free PMC Article
  2. The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis. Brugarolas P, et al. J Biol Chem, 2012 Nov 2. PMID 22992749, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study simulated MosR (Rv1049) unbound to the DNA, both in the presence and in the absence of the disulphide bond; results indicate that this disulphide bond precludes the N-terminal residues from adopting a conformation that stands in-between the helix alpha1 and the DNA binding domain (DBD) from the other chain
    Title: Computer simulations reveal changes in the conformational space of the transcriptional regulator MosR upon the formation of a disulphide bond and in the collective motions that regulate its DNA-binding affinity.
  2. Data show that the main role of the oxidation-sensing regulator, Rv1049 or MosR, is to up-regulate expression of rv1050 (a putative exported oxidoreductase) in response to oxidants.
    Title: The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
transcriptional repressor
NP_215565.1
  • This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1172386..1172832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215565.1 transcriptional repressor [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215565.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W5E8
    Conserved Domains (1) summary
    COG1846
    Location:17 → 134
    MarR; DNA-binding transcriptional regulator, MarR family [Transcription]
Nucleotide Protein
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