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cysK1 O-acetylserine sulfhydrylase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886016, updated on 6-Oct-2023
Gene symbol
cysK1
Gene description
O-acetylserine sulfhydrylase
Locus tag
Rv2334
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
cysK
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Sequence:
NC_000962.3 (2608796..2609728)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene malate oxidoreductase Neighboring gene multidrug resistance protein Neighboring gene serine acetyltransferase Neighboring gene hypothetical protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Comparative thermodynamic studies on substrate and product binding of O-acetylserine sulfhydrylase reveals two different ligand recognition modes. Banerjee S, et al. BMC Biochem, 2011 Jun 2. PMID 21631959, Free PMC Article
  2. Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis. Crystal structures of the enzyme alpha-aminoacrylate intermediate and an enzyme-inhibitor complex. Schnell R, et al. J Biol Chem, 2007 Aug 10. PMID 17567578
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. O-acetylserine sulfhydrylase has predominantly entropy driven methionine binding is not mediated through classical hydrophobic binding, instead, may involve desolvation of the polar active site.
    Title: Comparative thermodynamic studies on substrate and product binding of O-acetylserine sulfhydrylase reveals two different ligand recognition modes.
  2. analysis of catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis
    Title: Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis. Crystal structures of the enzyme alpha-aminoacrylate intermediate and an enzyme-inhibitor complex.
Submit: New GeneRIF Correction

Homology

Preferred Names
O-acetylserine sulfhydrylase
YP_177868.1
  • cysteine synthase CysK (O-acetylserine (thiol)-lyase A) (CSASE A)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2608796..2609728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177868.1 O-acetylserine sulfhydrylase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177868.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W968
    Conserved Domains (1) summary
    TIGR01139
    Location:7 → 305
    cysK; cysteine synthase A
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WP55.1

Gene LinkOut

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