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CCKAR cholecystokinin A receptor [ Homo sapiens (human) ]

Gene ID: 886, updated on 18-Aug-2020

Summary

Official Symbol
CCKARprovided by HGNC
Official Full Name
cholecystokinin A receptorprovided by HGNC
Primary source
HGNC:HGNC:1570
See related
Ensembl:ENSG00000163394 MIM:118444
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCK-A; CCK1R; CCKRA; CCK1-R
Summary
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]
Expression
Biased expression in gall bladder (RPKM 17.2) and stomach (RPKM 6.8) See more
Orthologs

Genomic context

See CCKAR in Genome Data Viewer
Location:
4p15.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (26481396..26490484, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (26483018..26492042, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374545 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region Neighboring gene uncharacterized LOC105374542 Neighboring gene TBC1 domain family member 19 Neighboring gene STIM2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholecystokinin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholecystokinin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
axonogenesis IEA
Inferred from Electronic Annotation
more info
 
cholecystokinin signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of hormone secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cholecystokinin receptor type A
Names
CCK-A receptor
CCK-AR
cholecystokinin type-A receptor
cholecystokinin-1 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012053.1 RefSeqGene

    Range
    4937..14025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000730.3NP_000721.1  cholecystokinin receptor type A

    See identical proteins and their annotated locations for NP_000721.1

    Status: REVIEWED

    Source sequence(s)
    AC093637, L19315
    Consensus CDS
    CCDS3438.1
    UniProtKB/Swiss-Prot
    P32238
    Related
    ENSP00000295589.3, ENST00000295589.4
    Conserved Domains (3) summary
    pfam00001
    Location:58370
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam09193
    Location:147
    CholecysA-Rec_N; Cholecystokinin A receptor, N-terminal
    cl21561
    Location:48196
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    26481396..26490484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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