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higB toxin HigB [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885966, updated on 6-Oct-2023

Summary

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Gene symbol
higB
Gene description
toxin HigB
Locus tag
Rv1955
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (2201719..2202096)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene antitoxin VapB14 Neighboring gene ribonuclease VapC14 Neighboring gene hypothetical protein Neighboring gene antitoxin HigA Neighboring gene SecB-like chaperone Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA. Schuessler DL, et al. Mol Microbiol, 2013 Oct. PMID 23927792, Free PMC Article
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Authors show that expression of HigB toxin in the absence of HigA antitoxin arrests growth and causes cell death in Mycobacterium tuberculosis.
    Title: Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA.
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General gene information

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Homology

General protein information

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Preferred Names
toxin HigB
NP_216471.2
  • part of toxin-antitoxin (TA) operon with Rv1956. Upon expression in E. coli has been shown to function as an antitoxin against Rv1956 (PubMed: 19016878); It is not clear if these conflicting results are due to expression in a heterologous system; In various publications, both gene names higA and higB have been assigned to both Rv1955 and Rv1956; we have chosen to call Rv1955 higB after consulting the authors.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2201719..2202096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216471.2 toxin HigB [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216471.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A655A2T9
    Conserved Domains (1) summary
    pfam05973
    Location:27 → 113
    Gp49; Phage derived protein Gp49-like (DUF891)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WJA5.1

Gene LinkOut

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Molecular Biology Databases