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higA antitoxin HigA [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885964, updated on 6-Oct-2023

Summary

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Gene symbol
higA
Gene description
antitoxin HigA
Locus tag
Rv1956
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (2202138..2202587)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene antitoxin VapB14 Neighboring gene ribonuclease VapC14 Neighboring gene hypothetical protein Neighboring gene toxin HigB Neighboring gene SecB-like chaperone Neighboring gene hypothetical protein Neighboring gene toxin ParE1 Neighboring gene antitoxin ParD1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA. Schuessler DL, et al. Mol Microbiol, 2013 Oct. PMID 23927792, Free PMC Article
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Authors show that expression of HigB toxin in the absence of HigA antitoxin arrests growth and causes cell death in Mycobacterium tuberculosis.
    Title: Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA.
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General gene information

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Homology

General protein information

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Preferred Names
antitoxin HigA
NP_216472.1
  • part of toxin-antitoxin (TA) operon with Rv1955. Upon expression in E.coli Rv1956 has been shown to function as a toxin inhibiting cell growth and colony formation that is neutralized by coexpression with Rv1955 (PubMed: 19016878); It is not clear if these conflicting results are due to expression in a heterologous system. The gene names higA and higB have been assigned to both Rv1955 and Rv1956; we have chosen to call Rv1956 higA after consulting the authors.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2202138..2202587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216472.1 antitoxin HigA [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216472.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W851
    Conserved Domains (1) summary
    cd00093
    Location:40 → 90
    HTH_XRE; Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WJA7.1

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Molecular Biology Databases