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dnaK chaperone protein DnaK [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885946, updated on 6-Oct-2023
Gene symbol
dnaK
Gene description
chaperone protein DnaK
Locus tag
Rv0350
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
hsp70
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Sequence:
NC_000962.3 (419835..421712)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene transcriptional regulator Neighboring gene hypothetical protein Neighboring gene stress response protein GrpE Neighboring gene chaperone protein DnaJ Neighboring gene heat shock protein transcriptional repressor HspR Neighboring gene PPE family protein PPE7

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Extracellular mycobacterial DnaK polarizes macrophages to the M2-like phenotype. Lopes RL, et al. PLoS One, 2014. PMID 25419575, Free PMC Article
  2. Mycobacterium tuberculosis Cpn60.2 and DnaK are located on the bacterial surface, where Cpn60.2 facilitates efficient bacterial association with macrophages. Hickey TB, et al. Infect Immun, 2009 Aug. PMID 19470749, Free PMC Article
  3. Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals. Bulut Y, et al. J Biol Chem, 2005 Jun 3. PMID 15809303
  4. DnaK dependence of the mycobacterial stress-responsive regulator HspR is mediated through its hydrophobic C-terminal tail. Bandyopadhyay B, et al. J Bacteriol, 2012 Sep. PMID 22753065, Free PMC Article
  5. Modulation of DNA-binding activity of Mycobacterium tuberculosis HspR by chaperones. Das Gupta T, et al. Microbiology (Reading), 2008 Feb. PMID 18227252

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The DnaK-HspR-HAIR binding pattern altered at high temperatures in the presence of aggregated alpha-casein substrate, suggesting that DnaK may indirectly be responding to heat stress in a feedback loop mechanism.
    Title: Role of DnaK in HspR-HAIR interaction of Mycobacterium tuberculosis.
  2. Data indicate that DnaK induces activated macrophages (M2) phenotype surface markers.
    Title: Extracellular mycobacterial DnaK polarizes macrophages to the M2-like phenotype.
  3. The C-terminal hydrophobic tail of HspR was found to play a significant role in determining its thermal stability and DnaK dependence properties.
    Title: DnaK dependence of the mycobacterial stress-responsive regulator HspR is mediated through its hydrophobic C-terminal tail.
  4. These findings suggest that while M. tuberculosis displays both surface-associated Cpn60.2 and DnaK, only Cpn60.2 demonstrates adhesin functionality with regard to macrophage interaction.
    Title: Mycobacterium tuberculosis Cpn60.2 and DnaK are located on the bacterial surface, where Cpn60.2 facilitates efficient bacterial association with macrophages.
  5. Chemically denatured HspR was renatured, the protein gained optimal activity only if one of these GroEL class chaperones was present along with DnaK
    Title: Modulation of DNA-binding activity of Mycobacterium tuberculosis HspR by chaperones.
  6. HSP65 and HSP70 from Mycobacterium tuberculosis signal via TLR4
    Title: Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals.
Submit: New GeneRIF Correction

Homology

Preferred Names
chaperone protein DnaK
NP_214864.1
  • heat shock protein 70 (heat shock 70 kDa protein) (HSP70)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    419835..421712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214864.1 chaperone protein DnaK [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_214864.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0U1XGD1, B3VHV1
    Conserved Domains (1) summary
    PRK00290
    Location:1 → 600
    dnaK; molecular chaperone DnaK; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WMJ9.1

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