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ndkA nucleoside diphosphate kinase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885905, updated on 6-Aug-2024

Summary

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Gene symbol
ndkA
Gene description
nucleoside diphosphate kinase
Locus tag
Rv2445c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
ndk
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Genomic context

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Sequence:
NC_000962.3 (2745314..2745724, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 50S ribosomal protein L21 Neighboring gene C4-dicarboxylate-transport transmembrane protein DctA Neighboring gene ribonuclease E Neighboring gene integral membrane protein Neighboring gene folylpolyglutamate synthase FolC Neighboring gene valine--tRNA ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intersubunit ionic interactions stabilize the nucleoside diphosphate kinase of Mycobacterium tuberculosis. Georgescauld F, et al. PLoS One, 2013. PMID 23526954, Free PMC Article
  2. Polyphosphate kinase 2: a modulator of nucleoside diphosphate kinase activity in mycobacteria. Sureka K, et al. Mol Microbiol, 2009 Dec. PMID 19843229
  3. Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity. Sun J, et al. PLoS Pathog, 2013. PMID 23874203, Free PMC Article
  4. Mycobacterium tuberculosis and Escherichia coli nucleoside diphosphate kinases lack multifunctional activities to process uracil containing DNA. Kumar P, et al. DNA Repair (Amst), 2004 Nov 2. PMID 15380104
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest Ndk contributes to virulence of Mycobacterium tuberculosis via attenuation of NADPH oxidase-mediated host innate immunity; Ndk binds to/inactivates small GTPase Rac1 (RAS-related C3 botulinum substrate 1) in macrophages.
    Title: Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity.
  2. The quaternary structure of nucleoside diphosphate kinase is essential for full enzymatic activity and for protein stability to thermal and chemical denaturation. Identified the intersubunit salt bridge Arg(80)-Asp(93) as essential for hexamer stability.
    Title: Intersubunit ionic interactions stabilize the nucleoside diphosphate kinase of Mycobacterium tuberculosis.
  3. Study presents evidence that PPK2 regulates the intracellular nucleotide pool by interacting with nucleoside diphosphate kinase.
    Title: Polyphosphate kinase 2: a modulator of nucleoside diphosphate kinase activity in mycobacteria.
  4. In contrast to the robust uracil excision activity reported for E. coli NDK, the Mycobacterium tuberculosis NDK preparation exhibited very poor excision of uracil from DNA.
    Title: Mycobacterium tuberculosis and Escherichia coli nucleoside diphosphate kinases lack multifunctional activities to process uracil containing DNA.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
nucleoside diphosphate kinase
NP_216961.1
  • NDK (NDP kinase) (nucleoside-2-P kinase)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2745314..2745724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216961.1 nucleoside diphosphate kinase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216961.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0E8NTH4, A0A0H3LFX5
    Conserved Domains (1) summary
    PRK00668
    Location:2 → 135
    ndk; mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WJH7.1

Gene LinkOut

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