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STK19 serine/threonine kinase 19 [ Homo sapiens (human) ]

Gene ID: 8859, updated on 10-Oct-2024

Summary

Official Symbol
STK19provided by HGNC
Official Full Name
serine/threonine kinase 19provided by HGNC
Primary source
HGNC:HGNC:11398
See related
Ensembl:ENSG00000204344 MIM:604977; AllianceGenome:HGNC:11398
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G11; RP1; D6S60; D6S60E; HLA-RP1
Summary
This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 19.3), testis (RPKM 9.7) and 25 other tissues See more
Orthologs
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Genomic context

See STK19 in Genome Data Viewer
Location:
6p21.33
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (31971175..31981446)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (31824380..31834652)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (31938952..31949223)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene negative elongation factor complex member E Neighboring gene microRNA 1236 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:31929542-31930741 Neighboring gene SKI2 subunit of superkiller complex Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31939702-31940412 Neighboring gene decapping exoribonuclease Neighboring gene complement C4A (Chido/Rodgers blood group) Neighboring gene CYP21A1P recombination region Neighboring gene tenascin XA (pseudogene) recombination region Neighboring gene cytochrome P450 family 21 subfamily A member 1, pseudogene Neighboring gene tenascin XA (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.
EBI GWAS Catalog
GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117388

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
inactive serine/threonine-protein kinase 19
Names
MHC class III HLA-RP1
nuclear serine/threonine protein kinase
serine/threonine-protein kinase 19
NP_004188.2
NP_115830.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004197.2NP_004188.2  inactive serine/threonine-protein kinase 19 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site in the coding region, compared to variant 2. It encodes isoform 1 which is shorter compared to isoform 2. Although isoforms 1 and 2 differ in the kinase domain, it appears that there is no difference in kinase activity between isoforms 1 and 2.
    Source sequence(s)
    AL645922
    Consensus CDS
    CCDS34417.2
    UniProtKB/Swiss-Prot
    A6NF95, A6NFW8, B0QZR5, P49842, Q13159, Q31617, Q5JP77, Q5ST72, Q5ST75
    UniProtKB/TrEMBL
    A0AAQ5BI79
    Related
    ENSP00000509445.1, ENST00000685781.1
    Conserved Domains (1) summary
    pfam10494
    Location:28251
    Stk19; Serine-threonine protein kinase 19
  2. NM_032454.1NP_115830.1  inactive serine/threonine-protein kinase 19 isoform 2

    See identical proteins and their annotated locations for NP_115830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2). Although isoforms 1 and 2 differ in the kinase domain, it appears that there is no difference in kinase activity between isoforms 1 and 2.
    Source sequence(s)
    AL049547
    UniProtKB/TrEMBL
    A0A1U9X8L3
    Related
    ENSP00000364482.4, ENST00000375333.4
    Conserved Domains (1) summary
    pfam10494
    Location:138365
    Stk19; Serine-threonine protein kinase 19

RNA

  1. NR_026717.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is alternatively spliced in the 5' region, compared to variant 2. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC110347

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    31971175..31981446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    3448602..3458873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    3218950..3229219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    3313211..3323483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    3227145..3237417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    3272364..3282635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    31824380..31834652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)