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nadE glutamine-dependent NAD(+) synthetase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885808, updated on 6-Aug-2024
Gene symbol
nadE
Gene description
glutamine-dependent NAD(+) synthetase
Locus tag
Rv2438c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (2734792..2736831, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene transmembrane protein Neighboring gene cyclase Neighboring gene ribokinase RbsK Neighboring gene transmembrane protein Neighboring gene hypothetical protein Neighboring gene glutamate 5-kinase protein Neighboring gene GTPase Obg

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Regulation of the intersubunit ammonia tunnel in Mycobacterium tuberculosis glutamine-dependent NAD+ synthetase. Chuenchor W, et al. Biochem J, 2012 Apr 15. PMID 22280445
  2. Regulation of active site coupling in glutamine-dependent NAD(+) synthetase. LaRonde-LeBlanc N, et al. Nat Struct Mol Biol, 2009 Apr. PMID 19270703
  3. Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD(+) synthetases. Chuenchor W, et al. Nat Commun, 2020 Jan 7. PMID 31911602, Free PMC Article
  4. Glutamine amidotransferase activity of NAD+ synthetase from Mycobacterium tuberculosis depends on an amino-terminal nitrilase domain. Bellinzoni M, et al. Res Microbiol, 2005 Mar. PMID 15748981
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Homo sapiens NAD(+) synthetase (hsNadE) lacks substrate specificity for glutamine over ammonia and displays a modest activation of the glutaminase domain compared to tbNadE.
    Title: Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD(+) synthetases.
  2. results provide new insight into the regulation of ammonia transport in the intermolecular tunnel of NadE
    Title: Regulation of the intersubunit ammonia tunnel in Mycobacterium tuberculosis glutamine-dependent NAD+ synthetase.
  3. The structure, the first of a glutamine-dependent NAD(+) synthetase, reveals a homooctameric subunit organization suggesting a tight dependence of catalysis on the quaternary structure.
    Title: Regulation of active site coupling in glutamine-dependent NAD(+) synthetase.
  4. glutamine-amidotransferase activity is mediated by an N-terminal domain belonging to the superfamily of nitrilases
    Title: Glutamine amidotransferase activity of NAD+ synthetase from Mycobacterium tuberculosis depends on an amino-terminal nitrilase domain.
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Homology

Preferred Names
glutamine-dependent NAD(+) synthetase
NP_216954.2
  • NAD(+) synthase [glutamine-hydrolysing]

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2734792..2736831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216954.2 glutamine-dependent NAD(+) synthetase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216954.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0E7XKF2, A0A0H3LBP4
    Conserved Domains (1) summary
    PRK02628
    Location:1 → 678
    nadE; NAD synthetase; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WJJ3.1

Gene LinkOut

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