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ppa inorganic pyrophosphatase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885775, updated on 6-Oct-2023
Gene symbol
ppa
Gene description
inorganic pyrophosphatase
Locus tag
Rv3628
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (4067423..4067911)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypoxanthine-guanine phosphoribosyltransferase Neighboring gene tRNA(Ile)-lysidine synthase Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene integral membrane protein Neighboring gene integral membrane protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis. Pratt AC, et al. J Struct Biol, 2015 Oct. PMID 26296329
  2. Structure of the Mycobacterium tuberculosis soluble inorganic pyrophosphatase Rv3628 at pH 7.0. Benini S, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Aug 1. PMID 21821883, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The active site of Mtb PPiase exhibits significant structural differences from the well characterized Escherichia coli PPiase in the vicinity of the bound PPi substrate.
    Title: Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis.
  2. Mutational and functional studies of the Mycobacterium tuberculosis inorganic pyrophosphatase showed that His21 and His86 are not essential for pyrophosphate hydrolysis
    Title: Structure of the Mycobacterium tuberculosis soluble inorganic pyrophosphatase Rv3628 at pH 7.0.
Submit: New GeneRIF Correction

Homology

Preferred Names
inorganic pyrophosphatase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4067423..4067911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218145.1 inorganic pyrophosphatase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218145.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M0K4
    Conserved Domains (1) summary
    pfam00719
    Location:5 → 158
    Pyrophosphatase; Inorganic pyrophosphatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WI55.1

Gene LinkOut

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Molecular Biology Databases