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pknD serine/threonine-protein kinase PknD [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885607, updated on 19-Jun-2021
Gene symbol
pknD
Gene description
serine/threonine-protein kinase PknD
Locus tag
Rv0931c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
mbk
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Sequence:
NC_000962.3 (1037920..1039914, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene phosphate ABC transporter substrate-binding lipoprotein PstS Neighboring gene phosphate ABC transporter permease PstC Neighboring gene phosphate ABC transporter permease PstA Neighboring gene phosphate ABC transporter substrate-binding lipoprotein PstS Neighboring gene phosphate ABC transporter ATP-binding protein PstB

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Effect of PstS sub-units or PknD deficiency on the survival of Mycobacterium tuberculosis. Vanzembergh F, et al. Tuberculosis (Edinb), 2010 Nov. PMID 20933472
  2. Allosteric activation by dimerization of the PknD receptor Ser/Thr protein kinase from Mycobacterium tuberculosis. Greenstein AE, et al. J Biol Chem, 2007 Apr 13. PMID 17242402
  3. Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD. Pérez J, et al. Biochem Biophys Res Commun, 2006 Sep 15. PMID 16879801
  4. Tuning the Mycobacterium tuberculosis Alternative Sigma Factor SigF through the Multidomain Regulator Rv1364c and Osmosensory Kinase Protein Kinase D. Misra R, et al. J Bacteriol, 2019 Apr 1. PMID 30642988, Free PMC Article
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data provide evidence that Rv1364c acts an independent SigF regulator that is sensitive to the osmosensory signal, mediating the cross talk of PknD with the SigF regulon.
    Title: Tuning the Mycobacterium tuberculosis Alternative Sigma Factor SigF through the Multidomain Regulator Rv1364c and Osmosensory Kinase Protein Kinase D.
  2. Results suggest that PstS1-3 may play a role in the regulation of M. tuberculosis growth or metabolism while PstS3 and PknD contribute to the survival of the bacteria in phosphate poor conditions.
    Title: Effect of PstS sub-units or PknD deficiency on the survival of Mycobacterium tuberculosis.
  3. dimer formation allosterically activates unphosphorylated PknD
    Title: Allosteric activation by dimerization of the PknD receptor Ser/Thr protein kinase from Mycobacterium tuberculosis.
  4. MmpL7 is a substrate for kinase PknD; Phosphorylation of MmpL7 by PknD could regulate their critical role in the formation of the M. tuberculosis envelope
    Title: Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD.
Submit: New GeneRIF Correction

Homology

Preferred Names
serine/threonine-protein kinase PknD
NP_215446.1
  • alternate gene name: mbk (protein kinase D) (STPK D). Belongs to the Ser/Thr family of protein kinases. Experimental studies show evidence of auto-phosphorylation on a serine residue. Appears to be co-transcribed with Rv0932c|pstS2.

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1037920..1039914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215446.1 serine/threonine-protein kinase PknD [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215446.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P9WI79
    UniProtKB/TrEMBL
    I6WZT2
    Conserved Domains (2) summary
    cd14014
    Location:14 → 271
    STKc_PknB_like; Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins
    cd14952
    Location:414 → 663
    NHL_PKND_like; NHL repeat domain of the protein kinase PknD
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WI79.1

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