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narL nitrate/nitrite response transcriptional regulator NarL [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885603, updated on 11-Dec-2020
Gene symbol
narL
Gene description
nitrate/nitrite response transcriptional regulator NarL
Locus tag
Rv0844c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (940456..941106, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene transmembrane protein Neighboring gene integral membrane protein Neighboring gene dehydrogenase Neighboring gene sensor histidine kinase NarS Neighboring gene oxidase

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. 1.9 A structure of the signal receiver domain of the putative response regulator NarL from Mycobacterium tuberculosis. Schnell R, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Dec 1. PMID 19052358, Free PMC Article
  2. FRET reveals multiple interaction states between two component signalling system proteins of M. tuberculosis. Agrawal R, et al. Biochim Biophys Acta, 2016 Jul. PMID 27102281
  3. Mycobacterium tuberculosis response regulators, DevR and NarL, interact in vivo and co-regulate gene expression during aerobic nitrate metabolism. Malhotra V, et al. J Biol Chem, 2015 Mar 27. PMID 25659431, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KdpDE/NarSL interact with each other in unphosphorylated state and phosphorylation affects the interaction, which is reflected as reduction in FRET ratio.
    Title: FRET reveals multiple interaction states between two component signalling system proteins of M. tuberculosis.
  2. NarL-DevR binding, possibly as a heterodimer, is a novel mechanism for co-regulation of gene expression by the DevRS/DosT and NarL/NarS regulatory systems.
    Title: Mycobacterium tuberculosis response regulators, DevR and NarL, interact in vivo and co-regulate gene expression during aerobic nitrate metabolism.
  3. A structure of the signal receiver domain of the putative response regulator NarL from Mycobacterium tuberculosis
    Title: 1.9 A structure of the signal receiver domain of the putative response regulator NarL from Mycobacterium tuberculosis.
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Homology

Preferred Names
nitrate/nitrite response transcriptional regulator NarL

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    940456..941106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215359.1 nitrate/nitrite response transcriptional regulator NarL [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215359.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    COG2197
    Location:10 → 216
    CitB; DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WGM5.1

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