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panC pantothenate synthetase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885459, updated on 6-Oct-2023

Summary

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Gene symbol
panC
Gene description
pantothenate synthetase
Locus tag
Rv3602c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (4044281..4045210, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene lysine--tRNA ligase Neighboring gene type III pantothenate kinase Neighboring gene aspartate 1-decarboxylase Neighboring gene hypothetical protein Neighboring gene transmembrane protein Neighboring gene hypothetical protein Neighboring gene 2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Design of Novel Mycobacterium tuberculosis Pantothenate Synthetase Inhibitors: Virtual Screening, Synthesis and In Vitro Biological Activities. Devi PB, et al. Mol Inform, 2015 Feb. PMID 27490037
  2. A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis. Kumar A, et al. PLoS One, 2013. PMID 24244263, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. report new inhibitors active against MTB PS developed using energy based pharmacophore modelling of the available proteininhibitor complex (3IVX) and virtual screening of a large commercial library. The e-pharmacophore model consisted of a ring aromatic (R), negative ionizable (N) and acceptor (A) sites.
    Title: Design of Novel Mycobacterium tuberculosis Pantothenate Synthetase Inhibitors: Virtual Screening, Synthesis and In Vitro Biological Activities.
  2. A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis.
    Title: A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
pantothenate synthetase
NP_218119.1
  • pantoate--beta-alanine ligase PanC; pantothenate synthetase (pantoate activating enzyme)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4044281..4045210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218119.1 pantothenate synthetase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218119.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M0I5
    Conserved Domains (1) summary
    pfam02569
    Location:19 → 284
    Pantoate_ligase; Pantoate-beta-alanine ligase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WIL5.1

Gene LinkOut

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Molecular Biology Databases
Research Materials