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uvrD1 ATP-dependent DNA helicase UvrD [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885442, updated on 27-Nov-2023
Gene symbol
uvrD1
Gene description
ATP-dependent DNA helicase UvrD
Locus tag
Rv0949
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
uvrD
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Sequence:
NC_000962.3 (1058260..1060575)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene chorismate mutase Neighboring gene hypothetical protein Neighboring gene succinyl-CoA ligase subunit beta

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Important role for Mycobacterium tuberculosis UvrD1 in pathogenesis and persistence apart from its function in nucleotide excision repair. Houghton J, et al. J Bacteriol, 2012 Jun. PMID 22467787, Free PMC Article
  2. Mycobacterium tuberculosis UvrD1 and UvrD2 helicases unwind G-quadruplex DNA. Saha T, et al. FEBS J, 2019 Jun. PMID 30821905
  3. Mycobacterium tuberculosis UvrD1 and UvrA proteins suppress DNA strand exchange promoted by cognate and noncognate RecA proteins. Singh P, et al. Biochemistry, 2010 Jun 15. PMID 20455546
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UvrD1 was proficient in resolving previously characterized tetramolecular G4 structures in an ATP hydrolysis and single-stranded 3'-tail-dependent manner. The G4 structures were derived from the potential G4 forming sequences present in the M. tuberculosis genome, suggesting an extended role for UvrD1 in resolving G4 DNA structures and the maintenance of genome integrity via G4 DNA resolution.
    Title: Mycobacterium tuberculosis UvrD1 and UvrD2 helicases unwind G-quadruplex DNA.
  2. Inactivation of uvrD1 resulted in a small colony phenotype and reduced pathogenicity.
    Title: Important role for Mycobacterium tuberculosis UvrD1 in pathogenesis and persistence apart from its function in nucleotide excision repair.
  3. M. tuberculosis UvrD1 more efficiently inhibits DNA strand exchange promoted by its cognate RecA, compared to noncognate Mycobacterium smegmatis or Escherichia coli RecA proteins.
    Title: Mycobacterium tuberculosis UvrD1 and UvrA proteins suppress DNA strand exchange promoted by cognate and noncognate RecA proteins.
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Homology

Preferred Names
ATP-dependent DNA helicase UvrD
YP_177772.1
  • ATP dependent DNA helicase II

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1058260..1060575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177772.1 ATP-dependent DNA helicase UvrD [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177772.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W537
    Conserved Domains (1) summary
    TIGR01073
    Location:19 → 768
    pcrA; ATP-dependent DNA helicase PcrA
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WMQ1.1

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