U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

folB dihydroneopterin aldolase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885345, updated on 6-Oct-2023
Gene symbol
folB
Gene description
dihydroneopterin aldolase
Locus tag
Rv3607c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
folX
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000962.3 (4048744..4049145, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene transmembrane protein Neighboring gene hypothetical protein Neighboring gene 2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase Neighboring gene dihydropteroate synthase Neighboring gene GTP cyclohydrolase I Neighboring gene zinc metalloprotease FtsH

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Validation of Mycobacterium tuberculosis dihydroneopterin aldolase as a molecular target for anti-tuberculosis drug development. Falcão VC, et al. Biochem Biophys Res Commun, 2017 Apr 15. PMID 28257847
  2. Characterization of a Mycobacterium tuberculosis nanocompartment and its potential cargo proteins. Contreras H, et al. J Biol Chem, 2014 Jun 27. PMID 24855650, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that folB gene essentiality depends on dihydroneopterin aldolase/epimerase activities of MtFolB protein.
    Title: Validation of Mycobacterium tuberculosis dihydroneopterin aldolase as a molecular target for anti-tuberculosis drug development.
  2. Mt-Enc encapsulation of three enzymes, Mt-DyP, Mt-BfrB, and Mt-FolB.
    Title: Characterization of a Mycobacterium tuberculosis nanocompartment and its potential cargo proteins.
Submit: New GeneRIF Correction

Homology

Preferred Names
dihydroneopterin aldolase

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4048744..4049145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177996.1 dihydroneopterin aldolase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177996.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7WD24
    Conserved Domains (1) summary
    cd00534
    Location:2 → 115
    DHNA_DHNTPE; Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
1Z9W_A.1
P9WNC5.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases