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Rv0805 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885326, updated on 6-Oct-2023
Gene symbol
Rv0805
Gene description
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Locus tag
Rv0805
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (898831..899787)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene succinyl-CoA transferase Neighboring gene phosphoribosylformylglycinamidine synthase 2 Neighboring gene hypothetical protein Neighboring gene exopolysaccharide phosphotransferase CpsY Neighboring gene hypothetical protein Neighboring gene amidophosphoribosyltransferase

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The non-catalytic "cap domain" of a mycobacterial metallophosphoesterase regulates its expression and localization in the cell. Matange N, et al. J Biol Chem, 2014 Aug 8. PMID 24970891, Free PMC Article
  2. Overexpression of the Rv0805 phosphodiesterase elicits a cAMP-independent transcriptional response. Matange N, et al. Tuberculosis (Edinb), 2013 Sep. PMID 23835087, Free PMC Article
  3. A mycobacterial cyclic AMP phosphodiesterase that moonlights as a modifier of cell wall permeability. Podobnik M, et al. J Biol Chem, 2009 Nov 20. PMID 19801656, Free PMC Article
  4. Structural and biochemical analysis of the Rv0805 cyclic nucleotide phosphodiesterase from Mycobacterium tuberculosis. Shenoy AR, et al. J Mol Biol, 2007 Jan 5. PMID 17059828
  5. The Rv0805 gene from Mycobacterium tuberculosis encodes a 3',5'-cyclic nucleotide phosphodiesterase: biochemical and mutational analysis. Shenoy AR, et al. Biochemistry, 2005 Dec 6. PMID 16313172

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mycobacterial phosphodiesterase Rv0805 is a virulence determinant and its cyclic nucleotide hydrolytic activity is required for propionate detoxification.
    Title: Mycobacterial phosphodiesterase Rv0805 is a virulence determinant and its cyclic nucleotide hydrolytic activity is required for propionate detoxification.
  2. Using a panel of mutant proteins, we identify interactions between active site residues of Rv0805 and the C-terminal extension that determine its association with the cell wall.
    Title: The non-catalytic "cap domain" of a mycobacterial metallophosphoesterase regulates its expression and localization in the cell.
  3. The study demonstrates the dissociation of Rv0805 and cAMP-regulated gene expression, and reveals alternate functions for this phosphodiesterase from M. tuberculosis.
    Title: Overexpression of the Rv0805 phosphodiesterase elicits a cAMP-independent transcriptional response.
  4. Rv0805 may play a key role in the pathogenicity of mycobacteria, not only by hydrolyzing bacterial cAMP, but also by moonlighting as a protein that can alter cell wall functioning
    Title: A mycobacterial cyclic AMP phosphodiesterase that moonlights as a modifier of cell wall permeability.
  5. The Rv0805 protein is a homologue of the cAMP phosphodiesterase present in Escherichia coli (cpdA). It hydrolyzes cAMP and cGMP in vitro, and overexpression in Mycobacterium smegmatis and E. coli reduces intracellular cAMP levels.
    Title: The Rv0805 gene from Mycobacterium tuberculosis encodes a 3',5'-cyclic nucleotide phosphodiesterase: biochemical and mutational analysis.
  6. The crystal structure of the Rv0805 dimer shows that the active site metals contribute to dimerization and thus play an additional structural role apart from their involvement in catalysis.
    Title: Structural and biochemical analysis of the Rv0805 cyclic nucleotide phosphodiesterase from Mycobacterium tuberculosis.
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Homology

Preferred Names
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
NP_215320.1
  • Class III Cyclic nucleotide phosphodiesterase (cNMP PDE)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    898831..899787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215320.1 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215320.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4LVM8
    Conserved Domains (1) summary
    cd07402
    Location:16 → 257
    MPP_GpdQ; Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WP65.1

Gene LinkOut

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Molecular Biology Databases