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pknF serine/threonine-protein kinase PknF [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885275, updated on 6-Oct-2023

Summary

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Gene symbol
pknF
Gene description
serine/threonine-protein kinase PknF
Locus tag
Rv1746
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1972138..1973568)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase PknE Neighboring gene membrane protein Neighboring gene isopentenyl-diphosphate delta-isomerase Neighboring gene ABC transporter ATP-binding protein/permease Neighboring gene hypothetical protein Neighboring gene integral membrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF. Rastogi S, et al. PLoS Pathog, 2021 Jul. PMID 34324582, Free PMC Article
  2. The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation. Leiba J, et al. Biochem Biophys Res Commun, 2014 Apr 18. PMID 24667600
  3. Role of Mycobacterium tuberculosis Ser/Thr kinase PknF: implications in glucose transport and cell division. Deol P, et al. J Bacteriol, 2005 May. PMID 15866927, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF.
    Title: Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF.
  2. EthR from M. tuberculosis is a specific substrate of the mycobacterial kinase PknF.
    Title: The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation.
  3. PknF plays a direct/indirect role in the regulation of glucose transport, cell growth, and septum formation in M. tuberculosis.
    Title: Role of Mycobacterium tuberculosis Ser/Thr kinase PknF: implications in glucose transport and cell division.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
serine/threonine-protein kinase PknF
NP_216262.1
  • protein kinase F (STPK F); Experimental studies show evidence of auto-phosphorylation. Start site chosen by homology, may extend further upstream.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1972138..1973568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216262.1 serine/threonine-protein kinase PknF [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216262.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0U0QRN3
    Conserved Domains (1) summary
    cd14014
    Location:11 → 274
    STKc_PknB_like; Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WI75.1

Gene LinkOut

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