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serC phosphoserine aminotransferase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885140, updated on 6-Oct-2023

Summary

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Gene symbol
serC
Gene description
phosphoserine aminotransferase
Locus tag
Rv0884c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (981424..982554, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene HTH-type transcriptional regulator Neighboring gene tRNA/rRNA methyltransferase Neighboring gene transmembrane protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene ferredoxin/ferredoxin--NADP reductase Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dysregulation of serine biosynthesis contributes to the growth defect of a Mycobacterium tuberculosis crp mutant. Bai G, et al. Mol Microbiol, 2011 Oct. PMID 21902733, Free PMC Article
  2. Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis. Coulibaly F, et al. Acta Crystallogr D Biol Crystallogr, 2012 May. PMID 22525753
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, the 1.5 A resolution crystal structure of Mtb phosphoserine aminotransferase (MtbPSAT) in complex with its cofactor, pyridoxal 5'-phosphate (PLP), is reported.
    Title: Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis.
  2. CRP binding directly activates both serC and Rv0885 expression.
    Title: Dysregulation of serine biosynthesis contributes to the growth defect of a Mycobacterium tuberculosis crp mutant.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
phosphoserine aminotransferase
NP_215399.1
  • Belongs to class-V of pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    981424..982554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215399.1 phosphoserine aminotransferase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215399.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W4V4
    Conserved Domains (1) summary
    TIGR01366
    Location:16 → 376
    serC_3; phosphoserine aminotransferase, putative
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WQ73.1

Gene LinkOut

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Molecular Biology Databases