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clpC1 ATP-dependent protease ATP-binding subunit ClpC [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885104, updated on 6-Oct-2023
Gene symbol
clpC1
Gene description
ATP-dependent protease ATP-binding subunit ClpC
Locus tag
Rv3596c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
clpC
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Sequence:
NC_000962.3 (4038158..4040704, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene PE-PGRS family protein PE_PGRS59 Neighboring gene iron-regulated H-NS-like protein Neighboring gene lysine--tRNA ligase

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini. Lunge A, et al. J Biol Chem, 2020 Jul 10. PMID 32409584, Free PMC Article
  2. Genome-wide interaction screen for Mycobacterium tuberculosis ClpCP protease reveals toxin-antitoxin systems as a major substrate class. Ziemski M, et al. FEBS J, 2021 Jan. PMID 32301575
  3. In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1. Gopal P, et al. ACS Infect Dis, 2017 Jul 14. PMID 28271875, Free PMC Article
  4. Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase. Schmitz KR, et al. Mol Microbiol, 2014 Aug. PMID 24976069, Free PMC Article
  5. The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1. Leodolter J, et al. PLoS One, 2015. PMID 25933022, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide interaction screen for Mycobacterium tuberculosis ClpCP protease reveals toxin-antitoxin systems as a major substrate class.
    Title: Genome-wide interaction screen for Mycobacterium tuberculosis ClpCP protease reveals toxin-antitoxin systems as a major substrate class.
  2. The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini.
    Title: The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini.
  3. It has been shown that the pyrazinoic acid/pyrazinamide resistance mechanisms due to panD and clpC1 missense mutations are recapitulated in vivo in a mouse model.
    Title: In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1.
  4. The Mycobacterium tuberculosis ClpP1-ClpP2 protease interacts asymmetrically with its ATPase partners ClpX and ClpC1.
    Title: The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1.
  5. Both ClpX and ClpC1 catalyse ATP-dependent unfolding and degradation of native protein substrates in conjunction with ClpP1P2, but neither mediates protein degradation with just ClpP1 or ClpP2.
    Title: Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase.
Submit: New GeneRIF Correction

Homology

Preferred Names
ATP-dependent protease ATP-binding subunit ClpC
YP_177995.1
  • Probable clpC1, ATP-dependent protease ATP-binding subunit

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4038158..4040704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177995.1 ATP-dependent protease ATP-binding subunit ClpC [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177995.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A655A8F3
    Conserved Domains (1) summary
    CHL00095
    Location:1 → 806
    clpC; Clp protease ATP binding subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WPC9.1

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