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mcr alpha-methylacyl-CoA racemase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885067, updated on 6-Oct-2023
Gene symbol
mcr
Gene description
alpha-methylacyl-CoA racemase
Locus tag
Rv1143
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (1270062..1271144)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene enoyl-CoA hydratase EchA11 Neighboring gene enoyl-CoA hydratase EchA10 Neighboring gene oxidoreductase Neighboring gene transmembrane transport protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The catalysis of the 1,1-proton transfer by alpha-methyl-acyl-CoA racemase is coupled to a movement of the fatty acyl moiety over a hydrophobic, methionine-rich surface. Bhaumik P, et al. J Mol Biol, 2007 Apr 6. PMID 17320106
  2. Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis. Mutational and structural characterization of the active site and the fold. Savolainen K, et al. J Biol Chem, 2005 Apr 1. PMID 15632186
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MCR has unique structural features, not seen in the structures of the sequence related formyl-CoA transferases
    Title: Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis. Mutational and structural characterization of the active site and the fold.
  2. The active site geometry agrees with a 1,1-proton transfer mechanism in which the acid/base-pair residues are His126 and Asp156.
    Title: The catalysis of the 1,1-proton transfer by alpha-methyl-acyl-CoA racemase is coupled to a movement of the fatty acyl moiety over a hydrophobic, methionine-rich surface.
Submit: New GeneRIF Correction

Homology

Preferred Names
alpha-methylacyl-CoA racemase
NP_215659.1
  • Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1270062..1271144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215659.1 alpha-methylacyl-CoA racemase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215659.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4LWI7
    Conserved Domains (1) summary
    COG1804
    Location:1 → 358
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2YIM_A.1
2YIM_B.1
2YIM_C.1
2YIM_D.1

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