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DLEU2 deleted in lymphocytic leukemia 2 [ Homo sapiens (human) ]

Gene ID: 8847, updated on 25-Sep-2022

Summary

Official Symbol
DLEU2provided by HGNC
Official Full Name
deleted in lymphocytic leukemia 2provided by HGNC
Primary source
HGNC:HGNC:13748
See related
Ensembl:ENSG00000231607 MIM:605766; AllianceGenome:HGNC:13748
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALT1; DLB2; LEU2; RFP2; BCMSUN; RFP2OS; MIR15AHG; TRIM13OS; LINC00022; NCRNA00022
Summary
This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle via angiotensin I converting enzyme 2 and cyclin D1. [provided by RefSeq, Dec 2017]
Expression
Ubiquitous expression in bone marrow (RPKM 1.5), testis (RPKM 1.3) and 25 other tissues See more
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Genomic context

See DLEU2 in Genome Data Viewer
Location:
13q14.2
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (49982549..50125541, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (49203159..49346123, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (50556685..50699677, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNY4 pseudogene 9 Neighboring gene SPRY domain containing 7 Neighboring gene microRNA 3613 Neighboring gene tripartite motif containing 13 Neighboring gene potassium channel regulator Neighboring gene microRNA 16-1 Neighboring gene microRNA 15a Neighboring gene ribosomal protein L18 pseudogene 10 Neighboring gene deleted in lymphocytic leukemia 1 Neighboring gene uncharacterized LOC124900337 Neighboring gene ST13, Hsp70 interacting protein pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • deleted in lymphocytic leukemia 2 (non-protein coding)
  • leukemia associated gene 2
  • long intergenic non-protein coding RNA 22
  • mir-15a-16-1 cluster host gene (non-protein coding)
  • ret finger protein 2 opposite strand

Clone Names

  • MGC88287

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_152566.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AF529010, AY455757
    Related
    ENST00000621282.4
  2. NR_152567.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137060
    Related
    ENST00000458725.8
  3. NR_152568.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137060
    Related
    ENST00000433070.8
  4. NR_152569.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BC038090, BG611461
    Related
    ENST00000421758.6
  5. NR_152570.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137060
    Related
    ENST00000449579.2
  6. NR_152571.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137060
  7. NR_152572.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137060

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    49982549..50125541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    49203159..49346123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_006021.1: Suppressed sequence

    Description
    NM_006021.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
  2. NR_002612.1: Suppressed sequence

    Description
    NR_002612.1: This RefSeq was removed because currently there is not sufficient support for the transcript.