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HCAR3 hydroxycarboxylic acid receptor 3 [ Homo sapiens (human) ]

Gene ID: 8843, updated on 1-Jun-2020

Summary

Official Symbol
HCAR3provided by HGNC
Official Full Name
hydroxycarboxylic acid receptor 3provided by HGNC
Primary source
HGNC:HGNC:16824
See related
Ensembl:ENSG00000255398 MIM:606039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCA3; HM74; PUMAG; Puma-g; GPR109B
Orthologs

Genomic context

See HCAR3 in Genome Data Viewer
Location:
12q24.31
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (122714756..122716811, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (123199303..123201439, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene hydroxycarboxylic acid receptor 2 Neighboring gene microRNA 9902-2 Neighboring gene hydroxycarboxylic acid receptor 1 Neighboring gene Sharpr-MPRA regulatory region 1215

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of hydroxycarboxylic acid receptor 3 (HCAR3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
hydroxycarboxylic acid receptor 3
Names
G-protein coupled receptor 109B
G-protein coupled receptor HM74
G-protein coupled receptor HM74B
GTP-binding protein
hydroxy-carboxylic acid receptor 3
niacin receptor 2
nicotinic acid receptor 2
putative chemokine receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006018.3NP_006009.2  hydroxycarboxylic acid receptor 3

    See identical proteins and their annotated locations for NP_006009.2

    Status: VALIDATED

    Source sequence(s)
    BC047891, BI908162, CB529340, CD366840, CU451507, DA948030, DA953971
    Consensus CDS
    CCDS53842.1
    UniProtKB/Swiss-Prot
    P49019
    Related
    ENSP00000436714.2, ENST00000528880.3
    Conserved Domains (1) summary
    pfam00001
    Location:44294
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    122714756..122716811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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