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GGH gamma-glutamyl hydrolase [ Homo sapiens (human) ]

Gene ID: 8836, updated on 7-Dec-2018

Summary

Official Symbol
GGHprovided by HGNC
Official Full Name
gamma-glutamyl hydrolaseprovided by HGNC
Primary source
HGNC:HGNC:4248
See related
Ensembl:ENSG00000137563 MIM:601509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GH
Summary
This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 36.6), liver (RPKM 31.0) and 19 other tissues See more
Orthologs

Genomic context

See GGH in Genome Data Viewer
Location:
8q12.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (63015079..63039051, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (63927638..63951610, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene sodium/potassium transporting ATPase interacting 3 Neighboring gene NKAIN3 intronic transcript Neighboring gene uncharacterized LOC107986946 Neighboring gene TAR DNA-binding protein 43-like Neighboring gene alpha tocopherol transfer protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Antifolate resistance, organism-specific biosystem (from KEGG)
    Antifolate resistance, organism-specific biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
  • Antifolate resistance, conserved biosystem (from KEGG)
    Antifolate resistance, conserved biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
  • Fluoropyrimidine Activity, organism-specific biosystem (from WikiPathways)
    Fluoropyrimidine Activity, organism-specific biosystemThe main mechanism of 5-FU activation is conversion to fluorodeoxyuridine monophosphate (FdUMP) which inhibits the enzyme thymidylate synthase (TYMS), an important part of the folate-homocysteine cyc...
  • Folate biosynthesis, organism-specific biosystem (from KEGG)
    Folate biosynthesis, organism-specific biosystem
    Folate biosynthesis
  • Folate biosynthesis, conserved biosystem (from KEGG)
    Folate biosynthesis, conserved biosystem
    Folate biosynthesis
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • glutamate removal from folates, organism-specific biosystem (from BIOCYC)
    glutamate removal from folates, organism-specific biosystemGeneral Background Folates are required in a variety of reactions (known as one-carbon metabolism), where they act as carriers of one-carbon units in various oxidation states. These one-carbon units...
  • glutathione-mediated detoxification, organism-specific biosystem (from BIOCYC)
    glutathione-mediated detoxification, organism-specific biosystemPlease note: This is a general detoxification pathway, where the first step can be catalyzed by many different enzymes, collectively known as glutathione transferases, or GSTs. In the first reaction,...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
exopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
gamma-glutamyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gamma-glutamyl-peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
omega peptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
neutrophil degranulation TAS
Traceable Author Statement
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to zinc ion IEA
Inferred from Electronic Annotation
more info
 
tetrahydrofolylpolyglutamate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
specific granule lumen TAS
Traceable Author Statement
more info
 
tertiary granule lumen TAS
Traceable Author Statement
more info
 
vacuole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
gamma-glutamyl hydrolase
Names
gamma-Glu-X carboxypeptidase
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
NP_003869.1
XP_011515925.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028126.1 RefSeqGene

    Range
    5001..28973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003878.3NP_003869.1  gamma-glutamyl hydrolase precursor

    See identical proteins and their annotated locations for NP_003869.1

    Status: REVIEWED

    Source sequence(s)
    BC025025
    Consensus CDS
    CCDS6177.1
    UniProtKB/Swiss-Prot
    Q92820
    Related
    ENSP00000260118.6, ENST00000260118.6
    Conserved Domains (1) summary
    cd01747
    Location:36306
    GATase1_Glutamyl_Hydrolase; Type 1 glutamine amidotransferase (GATase1) domain found in gamma-Glutamyl Hydrolase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    63015079..63039051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517623.3XP_011515925.1  gamma-glutamyl hydrolase isoform X1

    Conserved Domains (1) summary
    cl00020
    Location:36232
    GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
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