Format

Send to:

Choose Destination

GMPS guanine monophosphate synthase [ Homo sapiens (human) ]

Gene ID: 8833, updated on 5-Nov-2017
Official Symbol
GMPSprovided by HGNC
Official Full Name
guanine monophosphate synthaseprovided by HGNC
Primary source
HGNC:HGNC:4378
See related
Ensembl:ENSG00000163655 MIM:600358; Vega:OTTHUMG00000158551
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GATD7
Summary
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]
Orthologs
Location:
3q25.31
Exon count:
19
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (155869430..155943679)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (155588325..155657150)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene chromosome 3 open reading frame 33 Neighboring gene solute carrier family 33 member 1 Neighboring gene uncharacterized LOC105374174 Neighboring gene SET pseudogene 14 Neighboring gene vomeronasal 2 receptor 1 pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GMP synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
GMP synthase activity EXP
Inferred from Experiment
more info
PubMed 
GMP synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
GMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
GMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
purine nucleobase biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
purine ribonucleoside monophosphate biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
GMP synthase [glutamine-hydrolyzing]
Names
GMP synthase
GMP synthetase
MLL/GMPS fusion protein
glutamine amidotransferase
guanine monophosphate synthetase
guanosine 5'-monophosphate synthase
testicular tissue protein Li 82
NP_003866.1
XP_011511565.1
XP_016862911.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023247.1 RefSeqGene

    Range
    5001..72197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003875.2NP_003866.1  GMP synthase [glutamine-hydrolyzing]

    See identical proteins and their annotated locations for NP_003866.1

    Status: REVIEWED

    Source sequence(s)
    BC012178, BG721087, CB159072
    Consensus CDS
    CCDS46941.1
    UniProtKB/Swiss-Prot
    P49915
    UniProtKB/TrEMBL
    A0A140VJK6
    Related
    ENSP00000419851.1, OTTHUMP00000213048, ENST00000496455.6, OTTHUMT00000351260
    Conserved Domains (3) summary
    cd01742
    Location:28207
    GATase1_GMP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase
    PRK00074
    Location:28693
    guaA; GMP synthase; Reviewed
    cd01997
    Location:238692
    GMP_synthase_C; The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

    Range
    155869430..155943679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513263.2XP_011511565.1  GMP synthase [glutamine-hydrolyzing] isoform X1

    Conserved Domains (3) summary
    cd01742
    Location:34213
    GATase1_GMP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase
    PRK00074
    Location:34699
    guaA; GMP synthase; Reviewed
    cd01997
    Location:244698
    GMP_synthase_C; The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched ...
  2. XM_017007422.1XP_016862911.1  GMP synthase [glutamine-hydrolyzing] isoform X2

    Conserved Domains (3) summary
    cd01742
    Location:21200
    GATase1_GMP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase
    PRK00074
    Location:21686
    guaA; GMP synthase; Reviewed
    cd01997
    Location:231685
    GMP_synthase_C; The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched ...

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    155551614..155618831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center