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KYAT1 kynurenine aminotransferase 1 [ Homo sapiens (human) ]

Gene ID: 883, updated on 1-Jun-2020

Summary

Official Symbol
KYAT1provided by HGNC
Official Full Name
kynurenine aminotransferase 1provided by HGNC
Primary source
HGNC:HGNC:1564
See related
Ensembl:ENSG00000171097 Ensembl:ENSG00000286112 MIM:600547
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTK; KAT1; KATI; CCBL1
Summary
This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 2.6), skin (RPKM 1.9) and 25 other tissues See more
Orthologs

Genomic context

See KYAT1 in Genome Data Viewer
Location:
9q34.11
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128832942..128882523, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131595392..131644354, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 13 Neighboring gene SPOUT domain containing methyltransferase 1 Neighboring gene endonuclease G Neighboring gene leucine rich repeat containing 8 VRAC subunit A Neighboring gene uncharacterized LOC101929291 Neighboring gene phytanoyl-CoA dioxygenase domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ95217, MGC29624

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-S-conjugate beta-lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutamine-phenylpyruvate transaminase activity IEA
Inferred from Electronic Annotation
more info
 
kynurenine-oxoglutarate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kynurenine-oxoglutarate transaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
transaminase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
L-kynurenine catabolic process IEA
Inferred from Electronic Annotation
more info
 
L-phenylalanine catabolic process TAS
Traceable Author Statement
more info
 
cellular amino acid biosynthetic process TAS
Traceable Author Statement
more info
 
cellular modified amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
kynurenine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
tryptophan catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kynurenine--oxoglutarate transaminase 1
Names
beta-lysase, kidney
cysteine conjugate beta lyase 1
cysteine conjugate-beta lyase, cytoplasmic
cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)
cysteine-S-conjugate beta-lyase
glutamine transaminase K
glutamine--phenylpyruvate transaminase
glutamine-phenylpyruvate aminotransferase
kyneurenine aminotransferase
kynurenine aminotransferase I
kynurenine--oxoglutarate transaminase I
NP_001116143.1
NP_001116144.1
NP_001274319.1
NP_001339917.1
NP_001339918.1
NP_001339919.1
NP_001339920.1
NP_001339921.1
NP_001339922.1
NP_001339923.1
NP_001339924.1
NP_001339925.1
NP_001339926.1
NP_001339927.1
NP_001339928.1
NP_004050.3
XP_011517470.1
XP_011517471.1
XP_011517472.1
XP_016870751.1
XP_016870754.1
XP_016870756.1
XP_024303477.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122671.1NP_001116143.1  kynurenine--oxoglutarate transaminase 1 isoform a

    See identical proteins and their annotated locations for NP_001116143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 6-11 all encode the same isoform (a).
    Source sequence(s)
    AK291178, BU622726, DA381449, X82224
    Consensus CDS
    CCDS43884.1
    UniProtKB/Swiss-Prot
    Q16773
    UniProtKB/TrEMBL
    A8K563
    Conserved Domains (1) summary
    cl27741
    Location:24418
    Aminotran_1_2; Aminotransferase class I and II
  2. NM_001122672.1NP_001116144.1  kynurenine--oxoglutarate transaminase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the mid-coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    BU622726, DA381449, EL733697, X82224
    Consensus CDS
    CCDS48038.1
    UniProtKB/Swiss-Prot
    Q16773
    Related
    ENSP00000317342.6, ENST00000320665.10
    Conserved Domains (2) summary
    cd00609
    Location:31367
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PRK08912
    Location:24368
    PRK08912; hypothetical protein; Provisional
  3. NM_001287390.2NP_001274319.1  kynurenine--oxoglutarate transaminase 1 isoform c

    See identical proteins and their annotated locations for NP_001274319.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and CDS, and uses an alternate upstream translation start, compared to variant 1. The resulting protein (isoform c) has a longer N-terminus, compared to isoform a. Variants 4 and 12 both encode the same isoform (c).
    Source sequence(s)
    AL441992, AL672142
    Consensus CDS
    CCDS75915.1
    UniProtKB/TrEMBL
    B7Z4W5
    Related
    ENSP00000399415.2, ENST00000436267.7
    Conserved Domains (1) summary
    cl27741
    Location:118512
    Aminotran_1_2; Aminotransferase class I and II
  4. NM_001352988.1NP_001339917.1  kynurenine--oxoglutarate transaminase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 2, and 7-11, encodes isoform a.
    Source sequence(s)
    AL441992, AL672142
    Consensus CDS
    CCDS43884.1
    Conserved Domains (1) summary
    cl27741
    Location:24418
    Aminotran_1_2; Aminotransferase class I and II
  5. NM_001352989.1NP_001339918.1  kynurenine--oxoglutarate transaminase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 2, 6, and 8-11, encodes isoform a.
    Source sequence(s)
    AL441992, AL672142
    Consensus CDS
    CCDS43884.1
    Conserved Domains (1) summary
    cl27741
    Location:24418
    Aminotran_1_2; Aminotransferase class I and II
  6. NM_001352990.1NP_001339919.1  kynurenine--oxoglutarate transaminase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 2, 6, 7, and 9-11, encodes isoform a.
    Source sequence(s)
    AL441992, AL672142
    Consensus CDS
    CCDS43884.1
    Conserved Domains (1) summary
    cl27741
    Location:24418
    Aminotran_1_2; Aminotransferase class I and II
  7. NM_001352991.1NP_001339920.1  kynurenine--oxoglutarate transaminase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 1, 2, 6-8, 10, and 11, encodes isoform a.
    Source sequence(s)
    AL441992, AL672142
    Consensus CDS
    CCDS43884.1
    Conserved Domains (1) summary
    cl27741
    Location:24418
    Aminotran_1_2; Aminotransferase class I and II
  8. NM_001352992.1NP_001339921.1  kynurenine--oxoglutarate transaminase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 2, 6-9, and 11, encodes isoform a.
    Source sequence(s)
    AL441992, AL672142
    Consensus CDS
    CCDS43884.1
    Conserved Domains (1) summary
    cl27741
    Location:24418
    Aminotran_1_2; Aminotransferase class I and II
  9. NM_001352993.1NP_001339922.1  kynurenine--oxoglutarate transaminase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1, 2, and 6-10, encodes isoform a.
    Source sequence(s)
    AL441992
    Consensus CDS
    CCDS43884.1
    Conserved Domains (1) summary
    cl27741
    Location:24418
    Aminotran_1_2; Aminotransferase class I and II
  10. NM_001352994.1NP_001339923.1  kynurenine--oxoglutarate transaminase 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variant 4, encodes isoform c.
    Source sequence(s)
    AL441992, AL672142
    Consensus CDS
    CCDS75915.1
    Conserved Domains (1) summary
    cl27741
    Location:118512
    Aminotran_1_2; Aminotransferase class I and II
  11. NM_001352995.1NP_001339924.1  kynurenine--oxoglutarate transaminase 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variant 14, encodes isoform d.
    Source sequence(s)
    AL441992, AL672142
    Conserved Domains (1) summary
    cl27741
    Location:117511
    Aminotran_1_2; Aminotransferase class I and II
  12. NM_001352996.1NP_001339925.1  kynurenine--oxoglutarate transaminase 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variant 13, encodes isoform d.
    Source sequence(s)
    AL441992, AL672142
    Related
    ENSP00000498386.1, ENST00000651925.1
    Conserved Domains (1) summary
    cl27741
    Location:117511
    Aminotran_1_2; Aminotransferase class I and II
  13. NM_001352997.1NP_001339926.1  kynurenine--oxoglutarate transaminase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform e.
    Source sequence(s)
    AL441992, AL672142
    Conserved Domains (1) summary
    cl27741
    Location:58452
    Aminotran_1_2; Aminotransferase class I and II
  14. NM_001352998.1NP_001339927.1  kynurenine--oxoglutarate transaminase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform e.
    Source sequence(s)
    AL441992, AL672142
    Conserved Domains (1) summary
    cl27741
    Location:58452
    Aminotran_1_2; Aminotransferase class I and II
  15. NM_001352999.1NP_001339928.1  kynurenine--oxoglutarate transaminase 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL441992, AL672142
    Conserved Domains (1) summary
    cl27741
    Location:3360
    Aminotran_1_2; Aminotransferase class I and II
  16. NM_004059.5NP_004050.3  kynurenine--oxoglutarate transaminase 1 isoform a

    See identical proteins and their annotated locations for NP_004050.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the isoform a. Variants 1, 2, and 6-11 all encode the same isoform (a).
    Source sequence(s)
    AL441992, BI755163, DA381449, X82224
    Consensus CDS
    CCDS43884.1
    UniProtKB/Swiss-Prot
    Q16773
    UniProtKB/TrEMBL
    A8K563
    Related
    ENSP00000302227.3, ENST00000302586.8
    Conserved Domains (1) summary
    cl27741
    Location:24418
    Aminotran_1_2; Aminotransferase class I and II

RNA

  1. NR_109829.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL441992, AL672142
    Related
    ENST00000462722.5
  2. NR_148224.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL441992, AL672142
  3. NR_148225.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL441992
    Related
    ENST00000483599.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128832942..128882523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519169.1XP_011517471.1  kynurenine--oxoglutarate transaminase 1 isoform X4

    See identical proteins and their annotated locations for XP_011517471.1

    UniProtKB/Swiss-Prot
    Q16773
    UniProtKB/TrEMBL
    A8K563
    Conserved Domains (1) summary
    cl27741
    Location:24418
    Aminotran_1_2; Aminotransferase class I and II
  2. XM_017015267.1XP_016870756.1  kynurenine--oxoglutarate transaminase 1 isoform X4

    UniProtKB/Swiss-Prot
    Q16773
    UniProtKB/TrEMBL
    A8K563
    Conserved Domains (1) summary
    cl27741
    Location:24418
    Aminotran_1_2; Aminotransferase class I and II
  3. XM_017015262.1XP_016870751.1  kynurenine--oxoglutarate transaminase 1 isoform X2

    UniProtKB/TrEMBL
    B7Z4W5
    Conserved Domains (1) summary
    cl27741
    Location:118512
    Aminotran_1_2; Aminotransferase class I and II
  4. XM_011519170.2XP_011517472.1  kynurenine--oxoglutarate transaminase 1 isoform X4

    See identical proteins and their annotated locations for XP_011517472.1

    UniProtKB/Swiss-Prot
    Q16773
    UniProtKB/TrEMBL
    A8K563
    Conserved Domains (1) summary
    cl27741
    Location:24418
    Aminotran_1_2; Aminotransferase class I and II
  5. XM_017015265.1XP_016870754.1  kynurenine--oxoglutarate transaminase 1 isoform X4

    UniProtKB/Swiss-Prot
    Q16773
    UniProtKB/TrEMBL
    A8K563
    Conserved Domains (1) summary
    cl27741
    Location:24418
    Aminotran_1_2; Aminotransferase class I and II
  6. XM_011519168.1XP_011517470.1  kynurenine--oxoglutarate transaminase 1 isoform X4

    See identical proteins and their annotated locations for XP_011517470.1

    UniProtKB/Swiss-Prot
    Q16773
    UniProtKB/TrEMBL
    A8K563
    Conserved Domains (1) summary
    cl27741
    Location:24418
    Aminotran_1_2; Aminotransferase class I and II
  7. XM_024447709.1XP_024303477.1  kynurenine--oxoglutarate transaminase 1 isoform X5

    Conserved Domains (1) summary
    cl27741
    Location:3360
    Aminotran_1_2; Aminotransferase class I and II
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