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IQGAP1 IQ motif containing GTPase activating protein 1 [ Homo sapiens (human) ]

Gene ID: 8826, updated on 10-Dec-2024

Summary

Official Symbol
IQGAP1provided by HGNC
Official Full Name
IQ motif containing GTPase activating protein 1provided by HGNC
Primary source
HGNC:HGNC:6110
See related
Ensembl:ENSG00000140575 MIM:603379; AllianceGenome:HGNC:6110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAR1; p195; HUMORFA01
Summary
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 49.8), appendix (RPKM 48.4) and 25 other tissues See more
Orthologs
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Genomic context

See IQGAP1 in Genome Data Viewer
Location:
15q26.1
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (90388242..90502239)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (88144255..88258256)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90931474..91045471)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12979 Neighboring gene zinc finger protein 774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90938261-90938762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90938763-90939262 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6820 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:90955563-90956294 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:90957593-90958792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10077 Neighboring gene MPRA-validated peak2420 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr15:90999383-90999894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10078 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:91054233-91054732 Neighboring gene MPRA-validated peak2421 silencer Neighboring gene MPRA-validated peak2422 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10079 Neighboring gene CREB regulated transcription coactivator 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91106113-91106613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6824 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:91126557-91127068 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:91127069-91127580 Neighboring gene uncharacterized LOC124903555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91137296-91137796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10080 Neighboring gene Sharpr-MPRA regulatory region 4613 Neighboring gene uncharacterized LOC124903554

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify IQ motif containing GTPase activating protein 1 (IQGAP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify IQ motif containing GTPase activating protein 1 (IQGAP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify IQ motif containing GTPase activating protein 1 (IQGAP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify IQ motif containing GTPase activating protein 1 (IQGAP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0051

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
enables MAP-kinase scaffold activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables S100 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cadherin binding HDA PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in caveola assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to epidermal growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to platelet-derived growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in fibroblast migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic actomyosin contractile ring assembly actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in podocyte development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in actin filament TAS
Traceable Author Statement
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 
located_in slit diaphragm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ras GTPase-activating-like protein IQGAP1
Names
RasGAP-like with IQ motifs

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052946.1 RefSeqGene

    Range
    5002..118999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003870.4NP_003861.1  ras GTPase-activating-like protein IQGAP1

    See identical proteins and their annotated locations for NP_003861.1

    Status: REVIEWED

    Source sequence(s)
    AI924000, BC016714, D29640
    Consensus CDS
    CCDS10362.1
    UniProtKB/Swiss-Prot
    A7MBM3, P46940
    UniProtKB/TrEMBL
    A4QPB0
    Related
    ENSP00000268182.5, ENST00000268182.10
    Conserved Domains (6) summary
    smart00015
    Location:774796
    IQ; Calmodulin-binding motif
    cd05133
    Location:10031382
    RasGAP_IQGAP1; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 1
    smart00323
    Location:9921344
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:45159
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00201
    Location:685710
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam03836
    Location:14521580
    RasGAP_C; RasGAP C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    90388242..90502239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433204.1XP_047289160.1  ras GTPase-activating-like protein IQGAP1 isoform X1

    UniProtKB/TrEMBL
    A0A0J9YXZ5
    Related
    ENSP00000488618.1, ENST00000633485.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    88144255..88258256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379044.1XP_054235019.1  ras GTPase-activating-like protein IQGAP1 isoform X1

    UniProtKB/TrEMBL
    A0A0J9YXZ5