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oprP phosphate-specific outer membrane porin OprP [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 882442, updated on 11-Sep-2024
Gene symbol
oprP
Gene description
phosphate-specific outer membrane porin OprP
Locus tag
PA3279
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (3671227..3672549, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene short-chain dehydrogenase Neighboring gene hypothetical protein Neighboring gene pyrophosphate-specific outer membrane porin OprO Neighboring gene hypothetical protein

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Fosmidomycin transport through the phosphate-specific porins OprO and OprP of Pseudomonas aeruginosa. Piselli C, et al. Mol Microbiol, 2021 Jul. PMID 33561903
  2. Role of the central arginine R133 toward the ion selectivity of the phosphate specific channel OprP: effects of charge and solvation. Modi N, et al. Biochemistry, 2013 Aug 20. PMID 23875754
  3. Probing transport of fosfomycin through substrate specific OprO and OprP from Pseudomonas aeruginosa. Citak F, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29198700
  4. Why do the outer membrane proteins OmpF from E. coli and OprP from P. aeruginosa prefer trimers? Simulation studies. Niramitranon J, et al. J Mol Graph Model, 2016 Apr. PMID 26895142
  5. Structure, Dynamics, and Substrate Specificity of the OprO Porin from Pseudomonas aeruginosa. Modi N, et al. Biophys J, 2015 Oct 6. PMID 26445443, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fosmidomycin transport through the phosphate-specific porins OprO and OprP of Pseudomonas aeruginosa.
    Title: Fosmidomycin transport through the phosphate-specific porins OprO and OprP of Pseudomonas aeruginosa.
  2. Our analyzes show that OprO, and to a lesser degree OprP, have unexpected very high permeability to fosfomycin, so the antibiotic should be a potentially excellent alternative choice for the control of Pseudomonas aeruginosa infections.
    Title: Probing transport of fosfomycin through substrate specific OprO and OprP from Pseudomonas aeruginosa.
  3. The results suggest that trimerization is crucial for both structure and function of general porin OmpF in E. coli, whereas being trimer in substrate-specific channel OprP supports a pore function in Pseudomonas aeruginosa.
    Title: Why do the outer membrane proteins OmpF from E. coli and OprP from P. aeruginosa prefer trimers? Simulation studies.
  4. Study used x-ray crystallography, free-energy molecular dynamics (MD) simulations, and electrophysiology to uncover the atomic basis for the different substrate specificity of OprP and OprO
    Title: Structure, Dynamics, and Substrate Specificity of the OprO Porin from Pseudomonas aeruginosa.
  5. Data indicate the role of the R133 residue - particularly its charge and ability to change the solvation behavior of the permeating ion - in the structure-function relationship of outer membrane porin OprP.
    Title: Role of the central arginine R133 toward the ion selectivity of the phosphate specific channel OprP: effects of charge and solvation.
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Homology

Preferred Names
phosphate-specific outer membrane porin OprP
NP_251969.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    3671227..3672549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_251969.1 phosphate-specific outer membrane porin OprP [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_251969.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A367M642
    Conserved Domains (1) summary
    COG3746
    Location:1 → 440
    OprP; Phosphate-selective porin [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05695.3

Gene LinkOut

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