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lecA PA-I galactophilic lectin [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 882335, updated on 19-Nov-2025
Gene symbol
lecA
Gene description
PA-I galactophilic lectin
Locus tag
PA2570
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (2905182..2905550, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene tRNA-Leu Neighboring gene two-component sensor

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Secondary sugar binding site identified for LecA lectin from Pseudomonas aeruginosa. Blanchard B, et al. Proteins, 2014 Jun. PMID 24123124
  2. The galactophilic lectin (PA-IL, gene LecA) from Pseudomonas aeruginosa. Its binding requirements and the localization of lectin receptors in various mouse tissues. Kirkeby S, et al. Microb Pathog, 2006 May. PMID 16542817
  3. The galactophilic lectin, LecA, contributes to biofilm development in Pseudomonas aeruginosa. Diggle SP, et al. Environ Microbiol, 2006 Jun. PMID 16689730
  4. Structural basis of the preferential binding for globo-series glycosphingolipids displayed by Pseudomonas aeruginosa lectin I. Blanchard B, et al. J Mol Biol, 2008 Nov 21. PMID 18762193
  5. Role of water molecules in structure and energetics of Pseudomonas aeruginosa lectin I interacting with disaccharides. Nurisso A, et al. J Biol Chem, 2010 Jun 25. PMID 20410292, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LecA (PA-IL): A Galactose-Binding Lectin from Pseudomonas aeruginosa.
    Title: LecA (PA-IL): A Galactose-Binding Lectin from Pseudomonas aeruginosa.
  2. The crystal structure of LecA/melibiose complex shows a secondary sugar binding site with glucose bound.
    Title: Secondary sugar binding site identified for LecA lectin from Pseudomonas aeruginosa.
  3. Study established the structural features of PA-IL (LecA} in complex with the three disaccharides by docking and molecular dynamics simulations.
    Title: Role of water molecules in structure and energetics of Pseudomonas aeruginosa lectin I interacting with disaccharides.
  4. The results demonstrate that there is a relationship between the LecA and LecB lectins and the pathogenicity of P. aeruginosa.
    Title: Role of LecA and LecB lectins in Pseudomonas aeruginosa-induced lung injury and effect of carbohydrate ligands.
  5. Results describe the crystal structure of P. aeruginosa lectin I complexed to alphaGal1-3betaGal1-4Glc trisaccharide at 1.9-A resolution and reveal how the second galactose residue makes specific contacts with the protein surface.
    Title: Structural basis of the preferential binding for globo-series glycosphingolipids displayed by Pseudomonas aeruginosa lectin I.
  6. It is concluded that the carbohydrate recognizing site of the lectin can have a binding requirement of only one saccharide.
    Title: The galactophilic lectin (PA-IL, gene LecA) from Pseudomonas aeruginosa. Its binding requirements and the localization of lectin receptors in various mouse tissues.
  7. findings demonstrate that interferon-gamma binds to an outer membrane protein in Pseudomonas aeruginosa, OprF, resulting in the expression of a quorum-sensing dependent virulence determinant, the PA-I lectin
    Title: Recognition of host immune activation by Pseudomonas aeruginosa.
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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heterophilic cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
PA-I galactophilic lectin
NP_251260.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    2905182..2905550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_251260.1 PA-I galactophilic lectin [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_251260.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0N9LMY9
    Conserved Domains (1) summary
    pfam07828
    Location:2 → 122
    PA-IL; PA-IL-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05097.2

Gene LinkOut

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Molecular Biology Databases