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FGF16 fibroblast growth factor 16 [ Homo sapiens (human) ]

Gene ID: 8823, updated on 9-Dec-2024

Summary

Official Symbol
FGF16provided by HGNC
Official Full Name
fibroblast growth factor 16provided by HGNC
Primary source
HGNC:HGNC:3672
See related
Ensembl:ENSG00000196468 MIM:300827; AllianceGenome:HGNC:3672
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MF4; FGF-16
Summary
This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See FGF16 in Genome Data Viewer
Location:
Xq21.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (77447389..77457278)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (75884945..75894834)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (76709643..76712769)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373254 Neighboring gene Sharpr-MPRA regulatory region 14264 Neighboring gene SPRY domain containing 7 pseudogene 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:76642667-76643524 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:76643525-76644382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:76703913-76704414 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:76749658-76750240 Neighboring gene NANOG hESC enhancer GRCh37_chrX:76757869-76758370 Neighboring gene ATRX chromatin remodeler Neighboring gene fatty acid binding protein 5 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29779 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29780 Neighboring gene RNA, U6 small nuclear 854, pseudogene Neighboring gene magnesium transporter 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
fibroblast growth factor 16
Names
metacarpal 4-5 fusion

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034050.1 RefSeqGene

    Range
    4715..14604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003868.3NP_003859.1  fibroblast growth factor 16

    See identical proteins and their annotated locations for NP_003859.1

    Status: REVIEWED

    Source sequence(s)
    AC243316
    Consensus CDS
    CCDS75996.1
    UniProtKB/Swiss-Prot
    O43320
    UniProtKB/TrEMBL
    A0A7U3L5H2
    Related
    ENSP00000399324.2, ENST00000439435.3
    Conserved Domains (1) summary
    pfam00167
    Location:61187
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    77447389..77457278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    75884945..75894834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)