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dnr transcriptional regulator Dnr [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 882180, updated on 24-Aug-2024

Summary

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Gene symbol
dnr
Gene description
transcriptional regulator Dnr
Locus tag
PA0527
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (585980..586663, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene denitrification protein NorD Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene transcriptional regulator

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamics of the heme-binding bacterial gas-sensing dissimilative nitrate respiration regulator (DNR) and activation barriers for ligand binding and escape. Lobato L, et al. J Biol Chem, 2014 Sep 19. PMID 25037216, Free PMC Article
  2. A dramatic conformational rearrangement is necessary for the activation of DNR from Pseudomonas aeruginosa. Crystal structure of wild-type DNR. Giardina G, et al. Proteins, 2009 Oct. PMID 19415759
  3. The transcription factor DNR from Pseudomonas aeruginosa specifically requires nitric oxide and haem for the activation of a target promoter in Escherichia coli. Castiglione N, et al. Microbiology (Reading), 2009 Sep. PMID 19477902
  4. NO sensing in Pseudomonas aeruginosa: structure of the transcriptional regulator DNR. Giardina G, et al. J Mol Biol, 2008 May 16. PMID 18420222
  5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High-affinity sequence-specific DNA binding occurs only when DNR heme is nitrosylated, consistent with the proposed function of DNR as nitric oxide sensor.
    Title: Dynamics of the heme-binding bacterial gas-sensing dissimilative nitrate respiration regulator (DNR) and activation barriers for ligand binding and escape.
  2. DNR is able to discriminate in vivo between different diatomic signal molecules, NO and CO, both ligands of the reduced haem iron in vitro, suggesting that DNR responds specifically to NO.
    Title: The transcription factor DNR from Pseudomonas aeruginosa specifically requires nitric oxide and haem for the activation of a target promoter in Escherichia coli.
  3. Data suggests that DNR may undergo an unexpected and very large conformational rearrangement on activation.
    Title: A dramatic conformational rearrangement is necessary for the activation of DNR from Pseudomonas aeruginosa. Crystal structure of wild-type DNR.
  4. Results deascribe the three-dimensional structure of the sensor domain of the DNR from P. aeruginosa at 2.1 A resolution.
    Title: NO sensing in Pseudomonas aeruginosa: structure of the transcriptional regulator DNR.
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General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of oxidoreductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to nitric oxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
transcriptional regulator Dnr
NP_249218.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    585980..586663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_249218.1 transcriptional regulator Dnr [Pseudomonas aeruginosa PAO1]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A367MFI3
    Conserved Domains (1) summary
    COG0664
    Location:10 → 221
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
Nucleotide Protein
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