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wrbA NAD(P)H dehydrogenase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 882021, updated on 6-Oct-2023

Summary

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Gene symbol
wrbA
Gene description
NAD(P)H dehydrogenase
Locus tag
PA0949
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (1036579..1037175, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene DNA replication initiation factor Neighboring gene hypothetical protein Neighboring gene arsenate reductase Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pseudomonas aeruginosa MdaB and WrbA are water-soluble two-electron quinone oxidoreductases with the potential to defend against oxidative stress. Green LK, et al. J Microbiol, 2014 Sep. PMID 25085734
  2. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  3. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
  4. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article
  5. A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. Salunkhe P, et al. J Bacteriol, 2005 Jul. PMID 15995206, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Despite not conferring a growth advantage to wild type Pseudomonas aeruginosa, it is possible that the MdaB and WrbA quinone oxidoreductases defend against H2O2 toxicity at lower concentrations.
    Title: Pseudomonas aeruginosa MdaB and WrbA are water-soluble two-electron quinone oxidoreductases with the potential to defend against oxidative stress.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables NAD(P)H dehydrogenase (quinone) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
NAD(P)H dehydrogenase
NP_249640.1
  • Product name confidence: class 2 (High similarity to functionally studied protein)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    1036579..1037175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_249640.1 NAD(P)H dehydrogenase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_249640.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A367MA67
    Conserved Domains (1) summary
    cl00438
    Location:6 → 196
    FMN_red; NADPH-dependent FMN reductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I509.1

Gene LinkOut

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Molecular Biology Databases
Research Materials