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pmrB two-component regulator system signal sensor kinase PmrB [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881841, updated on 24-Aug-2024
Gene symbol
pmrB
Gene description
two-component regulator system signal sensor kinase PmrB
Locus tag
PA4777
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (5364760..5366193)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene two-component regulator system response regulator PmrA Neighboring gene protein CueR Neighboring gene hypothetical protein

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa. Bricio-Moreno L, et al. Nat Commun, 2018 Jul 6. PMID 29980663, Free PMC Article
  2. PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A. Moskowitz SM, et al. J Bacteriol, 2004 Jan. PMID 14702327, Free PMC Article
  3. Mutations in genes lpxL1, bamA, and pmrB impair the susceptibility of cystic fibrosis strains of Pseudomonas aeruginosa to murepavadin. Ghassani A, et al. Antimicrob Agents Chemother, 2024 Jan 10. PMID 38092672, Free PMC Article
  4. Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa. McPhee JB, et al. Mol Microbiol, 2003 Oct. PMID 14507375
  5. Resistance and Heteroresistance to Colistin in Pseudomonas aeruginosa Isolates from Wenzhou, China. Lin J, et al. Antimicrob Agents Chemother, 2019 Oct. PMID 31383654, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations in genes lpxL1, bamA, and pmrB impair the susceptibility of cystic fibrosis strains of Pseudomonas aeruginosa to murepavadin.
    Title: Mutations in genes lpxL1, bamA, and pmrB impair the susceptibility of cystic fibrosis strains of Pseudomonas aeruginosa to murepavadin.
  2. Both colistin resistance and heteroresistance in P. aeruginosa mainly involved alterations of the PmrAB regulatory system.
    Title: Resistance and Heteroresistance to Colistin in Pseudomonas aeruginosa Isolates from Wenzhou, China.
  3. P. aeruginosa pmrB mutations in Cystic fibrosis patients are subject to an evolutionary trade-off.
    Title: Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa.
  4. Results suggest that polymyxin B resistance among clinical isolates of P. aeruginosa is associated with alterations in two-component regulatory systems of phoPQ or pmrAB.
    Title: Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables phosphorelay sensor kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to antibiotic ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within phosphorelay signal transduction system IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
two-component regulator system signal sensor kinase PmrB
NP_253465.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5364760..5366193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253465.1 two-component regulator system signal sensor kinase PmrB [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253465.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0N9QPN0, C7EDC8, G9JLA4, H2FHA1, H2FHA2
    Conserved Domains (1) summary
    PRK10337
    Location:1 → 434
    PRK10337; sensor protein QseC; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HV31.1

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