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fur ferric uptake regulation protein [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881780, updated on 30-Jul-2025
Gene symbol
fur
Gene description
ferric uptake regulation protein
Locus tag
PA4764
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (5351675..5352079, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene heat shock protein GrpE Neighboring gene DNA repair protein RecN Neighboring gene outer membrane lipoprotein OmlA Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator. Deng Z, et al. Nat Commun, 2015 Jul 2. PMID 26134419, Free PMC Article
  2. Coordinate regulation of siderophore and exotoxin A production: molecular cloning and sequencing of the Pseudomonas aeruginosa fur gene. Prince RW, et al. J Bacteriol, 1993 May. PMID 8478325, Free PMC Article
  3. Role of the ferric uptake regulator of Pseudomonas aeruginosa in the regulation of siderophores and exotoxin A expression: purification and activity on iron-regulated promoters. Ochsner UA, et al. J Bacteriol, 1995 Dec. PMID 8522528, Free PMC Article
  4. Ferric uptake regulator mutants of Pseudomonas aeruginosa with distinct alterations in the iron-dependent repression of exotoxin A and siderophores in aerobic and microaerobic environments. Barton HA, et al. Mol Microbiol, 1996 Sep. PMID 8885270
  5. Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis. Wilderman PJ, et al. Proc Natl Acad Sci U S A, 2004 Jun 29. PMID 15210934, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings showed that Fur is dispensable for planktonic growth, while it is required for colony formation; this is because Fur protects P. aeruginosa colonies from toxicity exerted by the pyochelin siderophore
    Title: Ferric Uptake Regulator Fur Is Conditionally Essential in Pseudomonas aeruginosa.
  2. Fur recognizes DNA by using a combination of base readout through direct contacts in the major groove and shape readout through recognition of the minor-groove electrostatic potential by lysine.
    Title: Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator.
  3. Gln60Pro amino acid replacement in the regulatory Fur protein is responsible for the overproduction of pyoverdine in iron-deplete and iron-replete medium.
    Title: Effect of the amino acid substitution in the DNA-binding domain of the Fur regulator on production of pyoverdine.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ferrous iron binding TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription EXP
Inferred from Experiment
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of siderophore biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of protein-DNA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
ferric uptake regulation protein
NP_253452.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5351675..5352079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253452.1 ferric uptake regulation protein [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253452.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A367LX59
    Conserved Domains (1) summary
    cl21459
    Location:4 → 129
    HTH; Helix-turn-helix domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03456.1

Gene LinkOut

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Molecular Biology Databases
Research Materials